国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2014年
1期
26-28
,共3页
林建国%曾霞%许剑利%曾博洁
林建國%曾霞%許劍利%曾博潔
림건국%증하%허검리%증박길
宫颈癌%人乳头瘤病毒%血清可溶性肿瘤坏死因子受体
宮頸癌%人乳頭瘤病毒%血清可溶性腫瘤壞死因子受體
궁경암%인유두류병독%혈청가용성종류배사인자수체
Cervical cancer%Human papilloma virus%Soluble tumor necrosis factor receptors
目的 探究宫颈癌与人乳头瘤病毒(human papilloma virus,HPV)感染及血清可溶性肿瘤坏死因子受体(soluble tumor necrosis factor receptors,STNFR)水平之间的相关性.方法 将53例宫颈癌患者纳入病例组,50名体检健康者纳入对照组,收集并比较她们的临床资料、HPV感染状况、术前与术后的STNFR水平.结果 病例组HPV感染率为62.26％,高于对照组的HPV感染率(16.00％),两者差异有统计学意义(P＜0.01).在病例组中,术前HPV感染阳性患者血清中的STN-FR Ⅰ与STNFRⅡ水平(2210.52±1213.71pg· ml-1与3679.24±1088.15pg· m1-1)高于HPV感染阴性患者(1149.34 ±603.14pg· ml-1与2667.23±819.87pg· ml-1),差异有统计学意义(STNFRI:P=0.043；STNFRⅡ:P=0.047)；但术后HPV感染阳性与阴性者的STNFR Ⅰ与STNFRⅡ水平差异无统计学意义.病例组患者术后三个月血清STNFR Ⅰ(1080.31±249.67pg· ml-1)与STNFRⅡ水平(1896.32 ±211.75pg· ml-1)低于术前(STNFR I:1822.36±1128.16pg· ml-1,STNFRⅡ:3293.14±1021.58pg· ml-1),差异有统计学意义(STNFRI:P=0.039,STNFRⅡ:P=0.006).结论 宫颈癌的发生与HPV感染有关,也与血清STNFR Ⅰ与STNFRⅡ水平有相关性.
目的 探究宮頸癌與人乳頭瘤病毒(human papilloma virus,HPV)感染及血清可溶性腫瘤壞死因子受體(soluble tumor necrosis factor receptors,STNFR)水平之間的相關性.方法 將53例宮頸癌患者納入病例組,50名體檢健康者納入對照組,收集併比較她們的臨床資料、HPV感染狀況、術前與術後的STNFR水平.結果 病例組HPV感染率為62.26％,高于對照組的HPV感染率(16.00％),兩者差異有統計學意義(P＜0.01).在病例組中,術前HPV感染暘性患者血清中的STN-FR Ⅰ與STNFRⅡ水平(2210.52±1213.71pg· ml-1與3679.24±1088.15pg· m1-1)高于HPV感染陰性患者(1149.34 ±603.14pg· ml-1與2667.23±819.87pg· ml-1),差異有統計學意義(STNFRI:P=0.043；STNFRⅡ:P=0.047)；但術後HPV感染暘性與陰性者的STNFR Ⅰ與STNFRⅡ水平差異無統計學意義.病例組患者術後三箇月血清STNFR Ⅰ(1080.31±249.67pg· ml-1)與STNFRⅡ水平(1896.32 ±211.75pg· ml-1)低于術前(STNFR I:1822.36±1128.16pg· ml-1,STNFRⅡ:3293.14±1021.58pg· ml-1),差異有統計學意義(STNFRI:P=0.039,STNFRⅡ:P=0.006).結論 宮頸癌的髮生與HPV感染有關,也與血清STNFR Ⅰ與STNFRⅡ水平有相關性.
목적 탐구궁경암여인유두류병독(human papilloma virus,HPV)감염급혈청가용성종류배사인자수체(soluble tumor necrosis factor receptors,STNFR)수평지간적상관성.방법 장53례궁경암환자납입병례조,50명체검건강자납입대조조,수집병비교저문적림상자료、HPV감염상황、술전여술후적STNFR수평.결과 병례조HPV감염솔위62.26％,고우대조조적HPV감염솔(16.00％),량자차이유통계학의의(P＜0.01).재병례조중,술전HPV감염양성환자혈청중적STN-FR Ⅰ여STNFRⅡ수평(2210.52±1213.71pg· ml-1여3679.24±1088.15pg· m1-1)고우HPV감염음성환자(1149.34 ±603.14pg· ml-1여2667.23±819.87pg· ml-1),차이유통계학의의(STNFRI:P=0.043；STNFRⅡ:P=0.047)；단술후HPV감염양성여음성자적STNFR Ⅰ여STNFRⅡ수평차이무통계학의의.병례조환자술후삼개월혈청STNFR Ⅰ(1080.31±249.67pg· ml-1)여STNFRⅡ수평(1896.32 ±211.75pg· ml-1)저우술전(STNFR I:1822.36±1128.16pg· ml-1,STNFRⅡ:3293.14±1021.58pg· ml-1),차이유통계학의의(STNFRI:P=0.039,STNFRⅡ:P=0.006).결론 궁경암적발생여HPV감염유관,야여혈청STNFR Ⅰ여STNFRⅡ수평유상관성.
Objective To explore the relationship between cervical cancer and human papilloma virus(HPV) infection as well as soluble tumor necrosis factor receptors (STNFR).Methods A total of 53 patients with cervical cancer were enrolled in the case group,while 50 healthy subjects were included in the control group.Clinical data,HPV and STNFR testing results of two groups were collected,analyzed and compared.Results 62.26％ and 16.00％ subjects in case group and control group respectively got infected with HPV.There was significant difference between the infection rate(P ＜ 0.01).The level of STNFR Ⅰ and STNFR Ⅱ were 1842.65 ± 1124.35pg· ml-1 and 3248.60 ± 1048.65pg· ml-1 respectively in case group,which were significantly higher than that of control group (849.32 ± 228.74pg· ml-1 and 1653.27 ± 358.42pg· ml-1) (STNFRⅠ: P =0.043,STNFR Ⅱ: P =0.047).In the case group,the level of STNFR Ⅰ (2210.52 ± 1213.71pg· ml-1) and STNFR Ⅱ (3679.24 ± 1088.15pg· ml-1) in subjects with HPV infection were significantly higher than that of patients without HPV infection (STNFR Ⅰ: 1149.34 ± 603.14 pg· ml-1,STNFR Ⅱ2667.23 ± 819.87pg· ml-1) before surgery.However,after surgery,there were no statistically differences between the level of STNFR Ⅰ and STNFRⅡamong patients with or without HPV infection.In case group,the level of STNFR Ⅰ(1080.31 ±249.67pg· ml-1) and STNFRⅡ(1896.32 ±211.75pg· ml-1) after surgery were statistically lower than that before surgery(STNFR Ⅰ: 1822.36 ± 1128.16pg· ml-1,STNFR Ⅱ: 3293.14 ± 1021.58pg· ml-1) (STNFRⅠ: P =0.039,STNFRⅡ: P =0.006).Conclusions Cervical cancer were associated HPV infection and the level of STNFR Ⅰ and STNFRⅡ.
