CAJ | 학술논문

目的：观察卡泊三醇软膏和地奈德乳膏序贯疗法治疗寻常型斑块状银屑病的疗效和安全性。方法：将96例寻常型斑块状银屑病患者随机分为卡泊三醇组A组、地奈德乳膏B组和卡泊三醇软膏与地奈德乳膏序贯治疗组C组。A组患者每日仅外用卡泊三醇软膏2次；B组患者每日仅外用地奈德乳膏2次；C组按银屑病序贯疗法用药。三组患者在疗后的第2周、4周、6周根据银屑病皮损面积和严重度指数(PASI)评分评判疗效，根据不良事件发生率分析其安全性。结果：A组患者在治疗后2周、4周和6周的有效率分别为26.67％、56.67％和70.00％；B组患者的有效率分别为36.67％、67.67％和76.67％；C组患者的有效率分别为53.33％、73.33％和83.33％。地奈德和序贯疗法治疗组的有效率分别为76.67％和83.33％，高于卡泊三醇组的70.00％(P<0.05)；但序贯疗法组和地奈德组间差异无统计学意义。C组的不良事件发生率亦明显低于A、B组(P<0.01)。结论：地奈德乳膏治疗寻常型银屑病疗效优于卡泊三醇，但卡泊三醇软膏和地奈德乳膏序贯疗法治疗寻常型斑块状银屑病具有起效快、疗效好、不良反应小的优点。
목적：관찰잡박삼순연고화지내덕유고서관요법치료심상형반괴상은설병적료효화안전성。방법：장96례심상형반괴상은설병환자수궤분위잡박삼순조A조、지내덕유고B조화잡박삼순연고여지내덕유고서관치료조C조。A조환자매일부외용잡박삼순연고2차；B조환자매일부외용지내덕유고2차；C조안은설병서관요법용약。삼조환자재료후적제2주、4주、6주근거은설병피손면적화엄중도지수(PASI)평분평판료효，근거불량사건발생솔분석기안전성。결과：A조환자재치료후2주、4주화6주적유효솔분별위26.67％、56.67％화70.00％；B조환자적유효솔분별위36.67％、67.67％화76.67％；C조환자적유효솔분별위53.33％、73.33％화83.33％。지내덕화서관요법치료조적유효솔분별위76.67％화83.33％，고우잡박삼순조적70.00％(P<0.05)；단서관요법조화지내덕조간차이무통계학의의。C조적불량사건발생솔역명현저우A、B조(P<0.01)。결론：지내덕유고치료심상형은설병료효우우잡박삼순，단잡박삼순연고화지내덕유고서관요법치료심상형반괴상은설병구유기효쾌、료효호、불량반응소적우점。
Objective:To observe the efficacy and safety of sequential therapy of combined calcipotriol cream with Desonide cream in the treatment of plaque type psoriasis.Methods:96 patients with the treatment of plaque type psoriasis were randomly divided into three groups:group A were treated with calcipotriol cream twicedaily, group B were treated with Desonide cream twicedaily,group C were sequentially treated with calcipotriol cream followed by Desonide cream . The PASI scores were evaluated at the week 2,4,and 6 after the initialtion of the treatment.The safety of the treatment Was evaluated, too.Results:The effective rates in group A at the week 2,4,6 were 26.67%,56.67%and 70.00% respectively,The effective rates in group B were 36.67%,66.67%and76.67%respectively;The effective rates in group C were 53.33%,73.33%and 83.33%rectively;The total effective rate for desonide group and combination group was 76.67% and 83.33%.and it was higher than the rate for calcipotriol group(P<0.05),but there was not any statistically significant difference between the former two groups.The incidence of adverse reactions in group C was less than that in group A and B(P<0.01).Conclusions:The therapeutic effect of desonide Was better than that of calcipotriol applied for plaque psoriasis. There are advantages of the sequential therapy with calcipotriol cream followed by Desonide cream in the treatment of psoriasis:rapid and good response,as well as less adverse reactions.