中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
23期
409-410
,共2页
呼吸窘迫综合征%经鼻间歇正压通气%持续气道正压通气%早期早产儿
呼吸窘迫綜閤徵%經鼻間歇正壓通氣%持續氣道正壓通氣%早期早產兒
호흡군박종합정%경비간헐정압통기%지속기도정압통기%조기조산인
Respiratory distress syndrome%The nasal intermittent positive pressure ventilation%Continuous positive airway pressure%Premature babies
目的对新生儿呼吸窘迫综合征(RDS)的早产儿早期使用经鼻间歇正压通气(NIPPV)和经鼻持续气道正压通气(NCPAP)模式在有创呼吸支持率、疗效及并发症方面进行比较分析。方法随机对照试验，将胎龄28~34周患有RDS的新生儿分为早期使用NIPPV组和早期使用NCPAP组。观察患儿生后72h内的插管有创呼吸支持率、支气管肺发育不良(BPD)发生率及使用无创呼吸支持后1、12、24h二氧化碳分压(PaCO2)、氧分压(PaO2)及氧合指数(OI)。结果①NIPPV组生后72h内有创呼吸支持明显低于NCPAP组；NIPPV组OI在无创呼吸支持后1、12、24h均高于NCPAP组；NIPPV组无创呼吸支持后1、12、24hPaCO2明显低于NCPAP组；NIPPV组PaO2在无创呼吸支持后1、12、24h明显高于NCPAP组；(P＜0.05)。②两组患儿氧疗总时间NIPPV组低于NCPAP组，(P<0.05)。结论早期使用NIPPV与NCPAP相比，可明显降低RDS患儿气管插管有创呼吸支持率，增加潮气量及通气量，改善氧合，值得临床推广。
目的對新生兒呼吸窘迫綜閤徵(RDS)的早產兒早期使用經鼻間歇正壓通氣(NIPPV)和經鼻持續氣道正壓通氣(NCPAP)模式在有創呼吸支持率、療效及併髮癥方麵進行比較分析。方法隨機對照試驗，將胎齡28~34週患有RDS的新生兒分為早期使用NIPPV組和早期使用NCPAP組。觀察患兒生後72h內的插管有創呼吸支持率、支氣管肺髮育不良(BPD)髮生率及使用無創呼吸支持後1、12、24h二氧化碳分壓(PaCO2)、氧分壓(PaO2)及氧閤指數(OI)。結果①NIPPV組生後72h內有創呼吸支持明顯低于NCPAP組；NIPPV組OI在無創呼吸支持後1、12、24h均高于NCPAP組；NIPPV組無創呼吸支持後1、12、24hPaCO2明顯低于NCPAP組；NIPPV組PaO2在無創呼吸支持後1、12、24h明顯高于NCPAP組；(P＜0.05)。②兩組患兒氧療總時間NIPPV組低于NCPAP組，(P<0.05)。結論早期使用NIPPV與NCPAP相比，可明顯降低RDS患兒氣管插管有創呼吸支持率，增加潮氣量及通氣量，改善氧閤，值得臨床推廣。
목적대신생인호흡군박종합정(RDS)적조산인조기사용경비간헐정압통기(NIPPV)화경비지속기도정압통기(NCPAP)모식재유창호흡지지솔、료효급병발증방면진행비교분석。방법수궤대조시험，장태령28~34주환유RDS적신생인분위조기사용NIPPV조화조기사용NCPAP조。관찰환인생후72h내적삽관유창호흡지지솔、지기관폐발육불량(BPD)발생솔급사용무창호흡지지후1、12、24h이양화탄분압(PaCO2)、양분압(PaO2)급양합지수(OI)。결과①NIPPV조생후72h내유창호흡지지명현저우NCPAP조；NIPPV조OI재무창호흡지지후1、12、24h균고우NCPAP조；NIPPV조무창호흡지지후1、12、24hPaCO2명현저우NCPAP조；NIPPV조PaO2재무창호흡지지후1、12、24h명현고우NCPAP조；(P＜0.05)。②량조환인양료총시간NIPPV조저우NCPAP조，(P<0.05)。결론조기사용NIPPV여NCPAP상비，가명현강저RDS환인기관삽관유창호흡지지솔，증가조기량급통기량，개선양합，치득림상추엄。
Objective To neonatal respiratory distress syndrome (RDS) of premature infants early use of nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (NCPAP) model with a respiratory support, curative effect and complications of comparative analysis. Method randomized controlled trial, gestational age 28-34 weeks, babies born with RDS within 6h after divided into the early use of NIPPV group and early use of NCPAP. Observing children born within 72h after intubation and respiratory support, incidence of bronchial pulmonary dysplasia (BPD) and the use of noninvasive respiratory support 1, 12, 24h after carbon dioxide partial pressure (PaCO2), oxygen partial pressure (PaO2) and oxygenation index (OI). Result ①NIPPV group within 72h after birth of invasive respiratory support was signiifcantly lower than that in NCPAP group;NIPPV group OI in noninvasive respiratory support after 1, 12, 24h were higher than that in group NCPAP;group NIPPV noninvasive respiratory support after 1, 12, 24hPaCO2 were signiifcantly lower than those in group NCPAP;group NIPPV PaO2 in noninvasive respiratory support 1, 12, 24h were signiifcantly higher than that of NCPAP group (P<0.05).②two groups of children with oxygen therapy time of NIPPV group was lower than that of NCPAP group (P<0.05). Conclusion Early use of NIPPV compared with NCPAP, can obviously reduce the RDS with endotracheal intubation and respiratory support, increase in tidal volume and the ventilation, improve oxygenation, worth clinical promotion.
