中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
23期
405-405,407
,共2页
肖玉安%邱庆明%何梅%任维
肖玉安%邱慶明%何梅%任維
초옥안%구경명%하매%임유
尼卡地平%艾司洛尔%高血压%气管拔管%心血管反应
尼卡地平%艾司洛爾%高血壓%氣管拔管%心血管反應
니잡지평%애사락이%고혈압%기관발관%심혈관반응
Nicardipine%Esmolol%Hypertension%Extubation%Cardiovascular reaction
目的研究尼卡地平和艾司洛尔联合用药预防高血压患者气管拔管反应的效果。方法选择40例择期腹腔镜胆囊切除术合并高血压病史的患者，术毕具备拔管条件时随机分为对照组（A组）和观察组(B组),每组20例，拔管前A组静注等量生理盐水，B组静注尼卡地平0.02mg/kg和艾司洛尔0.1mg/kg，比较两组患者麻醉诱导前（T0）、用药后5min（T1）、拔管即刻（T2），拔管后5min（T3）和10min （T4）的收缩压（SBP）、舒张压（DBP）、心率（HR）变化。结果 T1与T0比较A组监测指标无明显变化，B组呈下降趋势，两组HR值差异有统计学意义（P＜0.05）；T2时段两组HR、SBP、DBP均上升，A组较B组升高幅度更大，监测值差异有统计学意义（P＜0.05）；T3、T4时段两组监测值均逐渐下降，SBP、DBP两组差异有统计学意义(P＜0.05)。结论拔管前静注尼卡地平和艾司洛尔可有效抑制高血压患者拔管时不良心血管反应的发生。
目的研究尼卡地平和艾司洛爾聯閤用藥預防高血壓患者氣管拔管反應的效果。方法選擇40例擇期腹腔鏡膽囊切除術閤併高血壓病史的患者，術畢具備拔管條件時隨機分為對照組（A組）和觀察組(B組),每組20例，拔管前A組靜註等量生理鹽水，B組靜註尼卡地平0.02mg/kg和艾司洛爾0.1mg/kg，比較兩組患者痳醉誘導前（T0）、用藥後5min（T1）、拔管即刻（T2），拔管後5min（T3）和10min （T4）的收縮壓（SBP）、舒張壓（DBP）、心率（HR）變化。結果 T1與T0比較A組鑑測指標無明顯變化，B組呈下降趨勢，兩組HR值差異有統計學意義（P＜0.05）；T2時段兩組HR、SBP、DBP均上升，A組較B組升高幅度更大，鑑測值差異有統計學意義（P＜0.05）；T3、T4時段兩組鑑測值均逐漸下降，SBP、DBP兩組差異有統計學意義(P＜0.05)。結論拔管前靜註尼卡地平和艾司洛爾可有效抑製高血壓患者拔管時不良心血管反應的髮生。
목적연구니잡지평화애사락이연합용약예방고혈압환자기관발관반응적효과。방법선택40례택기복강경담낭절제술합병고혈압병사적환자，술필구비발관조건시수궤분위대조조（A조）화관찰조(B조),매조20례，발관전A조정주등량생리염수，B조정주니잡지평0.02mg/kg화애사락이0.1mg/kg，비교량조환자마취유도전（T0）、용약후5min（T1）、발관즉각（T2），발관후5min（T3）화10min （T4）적수축압（SBP）、서장압（DBP）、심솔（HR）변화。결과 T1여T0비교A조감측지표무명현변화，B조정하강추세，량조HR치차이유통계학의의（P＜0.05）；T2시단량조HR、SBP、DBP균상승，A조교B조승고폭도경대，감측치차이유통계학의의（P＜0.05）；T3、T4시단량조감측치균축점하강，SBP、DBP량조차이유통계학의의(P＜0.05)。결론발관전정주니잡지평화애사락이가유효억제고혈압환자발관시불양심혈관반응적발생。
Objective Through combining the treatment of the Nicardipine and Esmolol, study the effect on preventing the reaction of the patients with hypertension after tracheal extubation. Methods Meeting the requirement of tracheal extubation after operation, to patients undergoing elective laparoscopic cholecystectomy combined history of hypertension are randomLy picked out and divided into group A and group B, 20 cases in each group. Before tracheal extubation, the patients from Group A are injected normal saline, while Nicardipine 0.02mg/kg and Esmolol 0.1mg/kg intravenous injections are given to the patients from group B. Compare all patients’ change of SBP, DBP, HR before anesthesia induction(T0), drug taking within 5min (T1), the moment after tracheal extubation (T2), tracheal extubation within 5min (T3) and 10min (T4). Results Comparing T1 with T0, monitoring index from group A has no change, but group B is on the decline. The differences between the two groups has statistical signiifcance (P<0.05). During T2, the HR、SBP、DBP of both groups are rising, which is much higher in group A than group B. Monitoring value difference is statistically signiifcant (P<0.05);T3, T4 time monitoring value of both groups is gradually on the decline. Differences of SBP, DBP have statistical signiifcance (P<0.05). Conclusion Nicardipine and Esmolol are given to the hypertension patients before tracheal extubation, it can effectively inhibit adverse cardiovascular reaction.
