CAJ | 학술논문

目的探讨细胞因子与血压昼夜节律的相关性。方法将84例高血压病患者分为杓型组35例，非杓型组49例，分别测定血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、γ-干拢素（IFN-γ），集落刺激因子-1(CSF-1)水平。结果非杓型组与杓型组比较， TNF-α、IL-6、CSF-1明显升高，IFN-γ明显降低；血压夜间下降与IFN-γ正相关,与TNF-α、IL-6、CSF-1负相关。多元线性回归分析， TNF-α、IL-6、CSF-1与夜间血压下降直线相关。结论细胞因子参与原发性高血压患者血压昼夜节律调节
목적탐토세포인자여혈압주야절률적상관성。방법장84례고혈압병환자분위표형조35례，비표형조49례，분별측정혈청종류배사인자-α（TNF-α）、백세포개소-6（IL-6）、γ-간롱소（IFN-γ），집락자격인자-1(CSF-1)수평。결과비표형조여표형조비교， TNF-α、IL-6、CSF-1명현승고，IFN-γ명현강저；혈압야간하강여IFN-γ정상관,여TNF-α、IL-6、CSF-1부상관。다원선성회귀분석， TNF-α、IL-6、CSF-1여야간혈압하강직선상관。결론세포인자삼여원발성고혈압환자혈압주야절률조절
Objective To investigate the correlation of cytokines and circadian blood pressure. Methods 84 patients with essential hypertension were divided into dipper group of 35 cases, 49 cases of non-dipper group were measured in serum itumor necrosis factor-α(TNF-α), nterleukin-6 (IL-6),γ-jamming prime (IFN-γ), colony stimulating factor-1 (CSF-1) levels. Results The non-dipper group dipper group comparison, TNF-α, IL-6, CSF-1 was signiifcantly higher, IFN-γis signiifcantly reduced;nighttime drop in blood pressure associated with TNF-α, IL-6, CSF-1 negative positively correlated with IFN-γ. Multiple linear regression analysis, IL-6, TNF-α, CSF-1 and nighttime blood pressure decreased linear correlation. Conclusion Cytokines involved in the circadian rhythm regulator of blood pressure in patients with essential hypertension.