CAJ | 학술논문

目的评价应用尼可地尔治疗冠状动脉慢血流现象（CSFP）的疗效及安全性。方法选择CSFP患者60例，按照随机、单盲和安慰剂对照的方法分为治疗组30例与对照组30例；观察治疗前、后两组临床症状的改善、胸痛发作频率与持续时间变化、6 min步行实验的改变和校正的血流分级（TIMI）血流计数及下降程度的变化，以及治疗前、后血常规及肝肾功能指标变化。结果尼可地尔治疗组改善临床症状有效率优于对照组（P＜0．01）；尼可地尔治疗后，胸痛发作频率和持续时间较前减少（P＜0．01，P＜0．05），6 min步行实验距离较前显著增加（P＜0．01），校正的TIMI血流计数较前显著降低（P＜0．01），且均优于对照组（P＜0．01）；患者血常规及肝肾功能检查治疗前、后均在正常范围（P＞0．05）。结论尼可地尔治疗CSFP有较好的疗效且应用安全。
목적평개응용니가지이치료관상동맥만혈류현상（CSFP）적료효급안전성。방법선택CSFP환자60례，안조수궤、단맹화안위제대조적방법분위치료조30례여대조조30례；관찰치료전、후량조림상증상적개선、흉통발작빈솔여지속시간변화、6 min보행실험적개변화교정적혈류분급（TIMI）혈류계수급하강정도적변화，이급치료전、후혈상규급간신공능지표변화。결과니가지이치료조개선림상증상유효솔우우대조조（P＜0．01）；니가지이치료후，흉통발작빈솔화지속시간교전감소（P＜0．01，P＜0．05），6 min보행실험거리교전현저증가（P＜0．01），교정적TIMI혈류계수교전현저강저（P＜0．01），차균우우대조조（P＜0．01）；환자혈상규급간신공능검사치료전、후균재정상범위（P＞0．05）。결론니가지이치료CSFP유교호적료효차응용안전。
Objective To evaluate the effect and safety of nicorandil on Coronary Slow Flow Phenomenon (CSFP) .Methods The CSFP patients(n=60) were randomly divided into the control group treated with placebo and the treatment group treated with nicorandil .The changes of the clinical symptoms ,the frequency and duration of pectoralgia ,the six-minute walk test ,and TIMI frame counts were observed before and after treatment .Results The treatment group had a better therapeutic effect than the con-trol group(P<0 .05) .There were significant differences in the frequency and duration of pectoralgia ,the six-minute walk test ,and TIMI frame counts in treatment group before and after treatment ,which were superior to those of control group (P<0 .05 ,P<0 .01) .The blood routine examinations and hepatorenal function were within the normal range before and after treatment .Conclusion Nicorandil has better therapeutic effect and safety on CSFP .