实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
2期
1-2,6
,共3页
徐咏书%方正旭%张清%孙坚
徐詠書%方正旭%張清%孫堅
서영서%방정욱%장청%손견
卒中相关性肺炎%干扰素-γ%白细胞介素-4%血清
卒中相關性肺炎%榦擾素-γ%白細胞介素-4%血清
졸중상관성폐염%간우소-γ%백세포개소-4%혈청
stroke-associated pneumonia%interferon-γ%interleukin-4%serum
目的:探讨卒中相关性肺炎患者血清Th1/Th2细胞因子[干扰素-γ(IFN-γ),白细胞介素-4(IL-4)]水平的变化及意义。方法采用酶联免疫吸附试验法(ELISA法)检测34例卒中相关性肺炎(卒中相关性肺炎组)、36例卒中(卒中组)和30例健康体检者(健康对照组)血清IFN-γ、IL-4水平。结果与健康对照组、卒中组比较,卒中相关性肺炎组血清IFN-γ、IFN-γ/IL-4比值均明显降低(均P<0.05),血清IL-4水平明显升高(P<0.05)。结论卒中相关性肺炎患者的IFN-γ减少,lL-4增多,Th1/Th2细胞介导的细胞免疫可能与卒中相关性肺炎的免疫功能失衡有关。
目的:探討卒中相關性肺炎患者血清Th1/Th2細胞因子[榦擾素-γ(IFN-γ),白細胞介素-4(IL-4)]水平的變化及意義。方法採用酶聯免疫吸附試驗法(ELISA法)檢測34例卒中相關性肺炎(卒中相關性肺炎組)、36例卒中(卒中組)和30例健康體檢者(健康對照組)血清IFN-γ、IL-4水平。結果與健康對照組、卒中組比較,卒中相關性肺炎組血清IFN-γ、IFN-γ/IL-4比值均明顯降低(均P<0.05),血清IL-4水平明顯升高(P<0.05)。結論卒中相關性肺炎患者的IFN-γ減少,lL-4增多,Th1/Th2細胞介導的細胞免疫可能與卒中相關性肺炎的免疫功能失衡有關。
목적:탐토졸중상관성폐염환자혈청Th1/Th2세포인자[간우소-γ(IFN-γ),백세포개소-4(IL-4)]수평적변화급의의。방법채용매련면역흡부시험법(ELISA법)검측34례졸중상관성폐염(졸중상관성폐염조)、36례졸중(졸중조)화30례건강체검자(건강대조조)혈청IFN-γ、IL-4수평。결과여건강대조조、졸중조비교,졸중상관성폐염조혈청IFN-γ、IFN-γ/IL-4비치균명현강저(균P<0.05),혈청IL-4수평명현승고(P<0.05)。결론졸중상관성폐염환자적IFN-γ감소,lL-4증다,Th1/Th2세포개도적세포면역가능여졸중상관성폐염적면역공능실형유관。
Objective To investigate the changes in serum Th1/Th2 cytokines,interferon-γ(IFN-γ) and interleukin-4 (IL-4),in patients with stroke-associated pneumonia (SAP)and their significance. Methods Serum levels of IFN-γ and IL-4 were measured by ELISA in 34 patients with SAP (SAP group),36 patients with stroke(stroke group)and 30 healthy subjects(control group).Results Compared with control group or stroke group,IFN-γlevels and IFN-γ/IL-4 ratios significantly decreased but IL-4 levels significantly increased in SAP group(P<0.05).Conclusion IFN-γ production decreases but IL-4 production increases in patients with SAP. Th1/Th2 cell-mediated immunity may be correlated with immune imbalance in SAP.