当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
12期
62-63
,共2页
参麦注射液%消化道肿瘤%化疗%不良反应
參麥註射液%消化道腫瘤%化療%不良反應
삼맥주사액%소화도종류%화료%불량반응
Shenmai injection%Gastrointestinal tumors%Chemotherapies%Adverse reactions
目的:探讨参麦注射液治疗消化道恶性肿瘤化疗后不良反应的效果。方法将中国人民解放军180医院2010年1月1日~2013年1月1日消化道肿瘤术后化疗患者60例随机均分为治疗组与对照组,对照组采用单纯化疗,治疗组在化疗基础上加用参麦注射液,2组均采用folfox6化疗方案(奥沙利铂静滴+氟尿嘧啶静脉泵入+亚叶酸钙静滴)。比较2组的不良反应发生情况。结果治疗组化疗后在神经毒性(56.7%VS 90%)、贫血(33.3%VS 76.7%)、白细胞总数(30%VS 60%)、血小板计数(26.7%VS 46.7%)、AST/ALT(13.3%VS 43.3%)、血糖升高(10%VS 26.7%)、低钾血症(13.4%VS 36.7%)、血液肌酐(0.67%VS 26.7%)、胃肠道反应(33.3%VS 63.3%)、全身乏力(46.7%VS 90%)等不良反应方面较对照组明显降低,2组有显著性差异(P<0.05)。结论参麦注射液在消化道恶性肿瘤术后化疗中能明显减轻化疗不良反应,从而减轻患者的痛苦,值得临床推广使用。
目的:探討參麥註射液治療消化道噁性腫瘤化療後不良反應的效果。方法將中國人民解放軍180醫院2010年1月1日~2013年1月1日消化道腫瘤術後化療患者60例隨機均分為治療組與對照組,對照組採用單純化療,治療組在化療基礎上加用參麥註射液,2組均採用folfox6化療方案(奧沙利鉑靜滴+氟尿嘧啶靜脈泵入+亞葉痠鈣靜滴)。比較2組的不良反應髮生情況。結果治療組化療後在神經毒性(56.7%VS 90%)、貧血(33.3%VS 76.7%)、白細胞總數(30%VS 60%)、血小闆計數(26.7%VS 46.7%)、AST/ALT(13.3%VS 43.3%)、血糖升高(10%VS 26.7%)、低鉀血癥(13.4%VS 36.7%)、血液肌酐(0.67%VS 26.7%)、胃腸道反應(33.3%VS 63.3%)、全身乏力(46.7%VS 90%)等不良反應方麵較對照組明顯降低,2組有顯著性差異(P<0.05)。結論參麥註射液在消化道噁性腫瘤術後化療中能明顯減輕化療不良反應,從而減輕患者的痛苦,值得臨床推廣使用。
목적:탐토삼맥주사액치료소화도악성종류화료후불량반응적효과。방법장중국인민해방군180의원2010년1월1일~2013년1월1일소화도종류술후화료환자60례수궤균분위치료조여대조조,대조조채용단순화료,치료조재화료기출상가용삼맥주사액,2조균채용folfox6화료방안(오사리박정적+불뇨밀정정맥빙입+아협산개정적)。비교2조적불량반응발생정황。결과치료조화료후재신경독성(56.7%VS 90%)、빈혈(33.3%VS 76.7%)、백세포총수(30%VS 60%)、혈소판계수(26.7%VS 46.7%)、AST/ALT(13.3%VS 43.3%)、혈당승고(10%VS 26.7%)、저갑혈증(13.4%VS 36.7%)、혈액기항(0.67%VS 26.7%)、위장도반응(33.3%VS 63.3%)、전신핍력(46.7%VS 90%)등불량반응방면교대조조명현강저,2조유현저성차이(P<0.05)。결론삼맥주사액재소화도악성종류술후화료중능명현감경화료불량반응,종이감경환자적통고,치득림상추엄사용。
Objective To study the effect of Shenmai injection in adverse reactions in the treatment of malignant tumors of digestive tract after chemotherapy effect. Methods 60 cases of digestive tract tumor after chemotherapy were randomly divided into treatment group and control group. The control group using a simple chemotherapy, the treatment group was treated with Shenmai injection in chemotherapy. Two groups were treated with FOLFOX 6 chemotherapy (oxaliplatin+5-FU intravenous drip intravenous folinic acid+calcium infusion). The daverse reaction of two groups were compared. Results The treatment of adverse reaction of chemotherapy treatment group was lower than that of control group in neurotoxicity (56.7%VS 90%), anemia(33.3%VS 76.7%), total white blood cells(30%VS 60%), blood platelet count(26.7%VS 46.7%),AST/ALT(13.3%VS 43.3%),hyper-glycemia (10%VS 26.7%),hypokalemia(13.4%VS 36.7%), creatinine(0.67%VS 26.7%), gastrointestinal reaction (33.3%VS 63.3%)and malaise(46.7%VS 90%).There was signiifcant difference between two groups (P<0.05). Conclusion Shenmai injection can alleviate the adverse reaction of chemotherapy in malignant tumor of digestive tract after chemotherapy, thereby reducing the pain of patients, is worthy of clinical use.