数理医药学杂志
數理醫藥學雜誌
수리의약학잡지
JOURNAL OF MATHEMATICAL MEDICINE
2013年
4期
454-456
,共3页
三小汤%慢性阻塞性肺病%急性发作期%IL-8%TNF-ɑ
三小湯%慢性阻塞性肺病%急性髮作期%IL-8%TNF-ɑ
삼소탕%만성조새성폐병%급성발작기%IL-8%TNF-ɑ
three small soup%chronic obstructive pulmonary disease%acute phase%IL-8%TNF-ɑ
目的：探讨中药复方三小汤治疗慢性阻塞性肺病急性期的作用机制。方法：以气管注脂多糖加熏烟方法制备慢阻肺急性发作期模型。通过观察给药前后各组大鼠咳嗽频率变化，并用双抗体夹心 ABC-ELISA 法检测大鼠血清内 IL-8、TNF-ɑ含量。观察大鼠模型给药前后的变化。结果：三小汤高剂量组、中剂量组与模型组比较显著降低模型大鼠咳嗽次数（P＜0．05）；三小汤高、中、低剂量组与模型组比较显著降低IL-8、TNF-ɑ含量。讨论：三小汤可以缓解慢性阻塞性肺病引起的咳嗽，降低血清内IL-8、TNF-ɑ含量可能是其疗效机制之一。
目的：探討中藥複方三小湯治療慢性阻塞性肺病急性期的作用機製。方法：以氣管註脂多糖加熏煙方法製備慢阻肺急性髮作期模型。通過觀察給藥前後各組大鼠咳嗽頻率變化，併用雙抗體夾心 ABC-ELISA 法檢測大鼠血清內 IL-8、TNF-ɑ含量。觀察大鼠模型給藥前後的變化。結果：三小湯高劑量組、中劑量組與模型組比較顯著降低模型大鼠咳嗽次數（P＜0．05）；三小湯高、中、低劑量組與模型組比較顯著降低IL-8、TNF-ɑ含量。討論：三小湯可以緩解慢性阻塞性肺病引起的咳嗽，降低血清內IL-8、TNF-ɑ含量可能是其療效機製之一。
목적：탐토중약복방삼소탕치료만성조새성폐병급성기적작용궤제。방법：이기관주지다당가훈연방법제비만조폐급성발작기모형。통과관찰급약전후각조대서해수빈솔변화，병용쌍항체협심 ABC-ELISA 법검측대서혈청내 IL-8、TNF-ɑ함량。관찰대서모형급약전후적변화。결과：삼소탕고제량조、중제량조여모형조비교현저강저모형대서해수차수（P＜0．05）；삼소탕고、중、저제량조여모형조비교현저강저IL-8、TNF-ɑ함량。토론：삼소탕가이완해만성조새성폐병인기적해수，강저혈청내IL-8、TNF-ɑ함량가능시기료효궤제지일。
Objective:To investigate the herbal compound three small soup treatment of chronic obstruc-tive pulmonary disease acute phase of the mechanism of action .Methods:T racheal injection of lipopolysac-charide plus fume prepared COPD acute exacerbation of the model .By observing the rats before and after ad-ministration of cough frequency changes by double antibody sandwich ABC-ELISA assay serum IL-8 ,TNF-ɑcontent .Changes in the rat model before and after administration were observed .Results :Three small soup high-dose group ,middle dose group and model group is significantly lower rat model of cough number of times (P<0 .05);three small soup high ,medium ,low dose group and model group comparison significant with the lowering of IL-8 ,of TNF-ɑ content .Donclusions :Three small soup can relieve cough caused by chronic obstructive pulmonary disease (COPD) ,lower serum IL-8 ,TNF-ɑcontent may be one of the mecha-nisms of its efficacy .
