CAJ | 학술논문

以二茂铁甲醛为起始原料，经过6步反应合成得到新型的二茂铁吡咯并[1，2-α]喹喔啉哌嗪类衍生物1a-h．产物针对恶性疟原虫FcB1， K1， F32等菌株进行了体外抑制活性实验．实验结果表明，新合成的化合物具有一定的抗疟活性，其中芳环上4-位硝基取代的化合物1h体外抗疟活性最优．本工作为进一步研究具有更好活性的抗疟药物打下一定的基础．
이이무철갑철위기시원료，경과6보반응합성득도신형적이무철필각병[1，2-α]규악람고진류연생물1a-h．산물침대악성학원충FcB1， K1， F32등균주진행료체외억제활성실험．실험결과표명，신합성적화합물구유일정적항학활성，기중방배상4-위초기취대적화합물1h체외항학활성최우．본공작위진일보연구구유경호활성적항학약물타하일정적기출．
A series of novel ferrocenyl-substituted pyrrolo [1,2-α] quinoxaline piperazines 1a-h were synthe-sized from ferrocene-carboxaldehyde by six-step reactions .All of the compounds were screened for their antimalarial activities against plasmodium falciparum FcB1, K1, F32 strains.The results revealed that compounds 1 exhibited some inhibitory activities against the plasmodium falciparum strains.Among them, nitro substituted 1h was best. This work laid a foundation for further study of new antimalarial drugs .