CAJ | 학술논문

目的：改进左乙拉西坦的合成方法。方法以（S）-2-氨基-丁酰胺盐酸盐为起始原料，经过酰化、环合制备左乙拉西坦。结果与结论：反应条件温和、时间短，易于控制，新合成方法可使总收率稳定在53%以上，高于文献报道的方法，降低了成本，更适合工业化的要求。
목적：개진좌을랍서탄적합성방법。방법이（S）-2-안기-정선알염산염위기시원료，경과선화、배합제비좌을랍서탄。결과여결론：반응조건온화、시간단，역우공제，신합성방법가사총수솔은정재53%이상，고우문헌보도적방법，강저료성본，경괄합공업화적요구。
Objective To improve synthesis method of Levetiracetam.Methods To (S) -2 - amino - butanamide hydrochloride as starting materials, acylation, cyclization levetiracetam.Results and conclusion Mild reaction conditions, time is short, easy to control, the new synthesis method enables stable overall yield of 53%or more,higher than reported in the literature method,more suitable for industrial requirements.