CAJ | 학술논문

运用循环伏安法研究了更昔洛韦在单壁碳纳米管修饰电极上的电化学行为，提出了一种简便、准确、灵敏的检测药物更昔洛韦的电化学分析方法．在pH 4．0的0．04 M B-R（磷酸＋冰醋酸＋硼酸）缓冲溶液中，更昔洛韦在单壁碳纳米管修饰电极上于1．08 V电位处有一峰形很好的氧化峰．与裸玻碳电极相比，更昔洛韦在单壁碳纳米管修饰电极上的电位负移了近30 mV，峰电流增加了近15倍，表明该修饰电极对更昔洛韦有较强的电催化作用．在最佳的试验条件下，氧化峰电流与更昔洛韦在3．5×10-7～1．2×10-5 M浓度范围内呈良好线性关系，检出限为1．8×10-8 M．该方法可用于药剂中更昔洛韦的分析．
운용순배복안법연구료경석락위재단벽탄납미관수식전겁상적전화학행위，제출료일충간편、준학、령민적검측약물경석락위적전화학분석방법．재pH 4．0적0．04 M B-R（린산＋빙작산＋붕산）완충용액중，경석락위재단벽탄납미관수식전겁상우1．08 V전위처유일봉형흔호적양화봉．여라파탄전겁상비，경석락위재단벽탄납미관수식전겁상적전위부이료근30 mV，봉전류증가료근15배，표명해수식전겁대경석락위유교강적전최화작용．재최가적시험조건하，양화봉전류여경석락위재3．5×10-7～1．2×10-5 M농도범위내정량호선성관계，검출한위1．8×10-8 M．해방법가용우약제중경석락위적분석．
In this paper , the electrochemical behavior of ganciclovir at a single -wall carbon nanotube ( SWCNT )-modified glassy carbon electrode ( GCE) is investigated by voltammetry .In a 0.04 M B-R buffer solution ( pH 4.0), ganciclovir exhibits a sensitive oxidation peak at ca .1.08 V ( vs.SCE).Compared with the bare glassy carbon electrode , the potential shifts negatively ca .30 mV, and the current increase nearly 15 times.The results show that the modified electrode has a high electrocatalytic activity toward ganciclovir .Under the optimal working conditions , the oxidation peak current of ganciclovir is linear with its concentration in the range of 3 .5 ×10 -7 ~1.2 ×10 -5 M and the detection limit is 1.8 ×10 -8 M.The proposed method is simple , rapid and sensitive , and can be used for determination of gancicloir in pharmaceutical formulation .