中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
7期
913-914
,共2页
高血压病%肿瘤坏死因子α%瘦素%可溶性血管内皮细胞黏附分子1
高血壓病%腫瘤壞死因子α%瘦素%可溶性血管內皮細胞黏附分子1
고혈압병%종류배사인자α%수소%가용성혈관내피세포점부분자1
Hypertension%Tumor necrosis factor α%Leptin%Soluble vascular cell adhesion molecule 1
目的 探讨高血压合并糖尿病患者中肿瘤坏死因子α(TNF-α)、瘦素、可溶性血管内皮细胞黏附分子1(sVCAM-1)含量的变化及其意义.方法 对34例高血压病患者(高血压组)、41例高血压合并糖尿病患者(合并组)和30名健康人(正常对照组)采用双抗体夹心法酶联免疫吸附测定(ELISA)检测血清TNF-α、瘦素和sVCAM-1含量；采用全自动血生化分析仪和化学发光法检测空腹血糖(FPG)和空腹胰岛素(FINS)含量,采用稳态模型评估法(HOMA)计算胰岛素抵抗指数(HOMA-IR).结果 ①高血压组、合并组血清TNF-α、瘦素和sVCAM-1水平及HOMA-IR均明显高于正常对照组[TNF-α:(29.7 ±2.6),(32.9 ±3.8)μg/L比(26.1±2.7) μg/L；瘦素:(5.9±1.2),(12.8±2.6) μg/L比(3.2±0.7) μg/L,sVCAM-1:(841±117),(947±113) μg/L比(678±87) μg/L,HOMA-IR:3.5 ±0.6,5.7±1.1比1.3±0.5](均P＜0.01)；高血压组与合并组之间以上各指标比较差异均有统计学意义(均P＜0.01).②高血压组、合并组TNF-α、瘦素和sVCAM-1水平与HOMA-IR呈正相关(r值分别为0.373、0.365、0.375,均P＜0.05；r值分别为0.518、0.469、0.674,均P ＜0.05).结论 ①TNF-α、瘦素和sVCAM-1是高血压病及高血压合并糖尿病发生发展的高危因素.②TNF-α、瘦素和sVCAM-1与胰岛素抵抗明显相关.
目的 探討高血壓閤併糖尿病患者中腫瘤壞死因子α(TNF-α)、瘦素、可溶性血管內皮細胞黏附分子1(sVCAM-1)含量的變化及其意義.方法 對34例高血壓病患者(高血壓組)、41例高血壓閤併糖尿病患者(閤併組)和30名健康人(正常對照組)採用雙抗體夾心法酶聯免疫吸附測定(ELISA)檢測血清TNF-α、瘦素和sVCAM-1含量；採用全自動血生化分析儀和化學髮光法檢測空腹血糖(FPG)和空腹胰島素(FINS)含量,採用穩態模型評估法(HOMA)計算胰島素牴抗指數(HOMA-IR).結果 ①高血壓組、閤併組血清TNF-α、瘦素和sVCAM-1水平及HOMA-IR均明顯高于正常對照組[TNF-α:(29.7 ±2.6),(32.9 ±3.8)μg/L比(26.1±2.7) μg/L；瘦素:(5.9±1.2),(12.8±2.6) μg/L比(3.2±0.7) μg/L,sVCAM-1:(841±117),(947±113) μg/L比(678±87) μg/L,HOMA-IR:3.5 ±0.6,5.7±1.1比1.3±0.5](均P＜0.01)；高血壓組與閤併組之間以上各指標比較差異均有統計學意義(均P＜0.01).②高血壓組、閤併組TNF-α、瘦素和sVCAM-1水平與HOMA-IR呈正相關(r值分彆為0.373、0.365、0.375,均P＜0.05；r值分彆為0.518、0.469、0.674,均P ＜0.05).結論 ①TNF-α、瘦素和sVCAM-1是高血壓病及高血壓閤併糖尿病髮生髮展的高危因素.②TNF-α、瘦素和sVCAM-1與胰島素牴抗明顯相關.
목적 탐토고혈압합병당뇨병환자중종류배사인자α(TNF-α)、수소、가용성혈관내피세포점부분자1(sVCAM-1)함량적변화급기의의.방법 대34례고혈압병환자(고혈압조)、41례고혈압합병당뇨병환자(합병조)화30명건강인(정상대조조)채용쌍항체협심법매련면역흡부측정(ELISA)검측혈청TNF-α、수소화sVCAM-1함량；채용전자동혈생화분석의화화학발광법검측공복혈당(FPG)화공복이도소(FINS)함량,채용은태모형평고법(HOMA)계산이도소저항지수(HOMA-IR).결과 ①고혈압조、합병조혈청TNF-α、수소화sVCAM-1수평급HOMA-IR균명현고우정상대조조[TNF-α:(29.7 ±2.6),(32.9 ±3.8)μg/L비(26.1±2.7) μg/L；수소:(5.9±1.2),(12.8±2.6) μg/L비(3.2±0.7) μg/L,sVCAM-1:(841±117),(947±113) μg/L비(678±87) μg/L,HOMA-IR:3.5 ±0.6,5.7±1.1비1.3±0.5](균P＜0.01)；고혈압조여합병조지간이상각지표비교차이균유통계학의의(균P＜0.01).②고혈압조、합병조TNF-α、수소화sVCAM-1수평여HOMA-IR정정상관(r치분별위0.373、0.365、0.375,균P＜0.05；r치분별위0.518、0.469、0.674,균P ＜0.05).결론 ①TNF-α、수소화sVCAM-1시고혈압병급고혈압합병당뇨병발생발전적고위인소.②TNF-α、수소화sVCAM-1여이도소저항명현상관.
Objective To investigate the change of serum tumor necrosis factor α(TNF-α),leptin,soluble vascular cell adhesion molecule-1 (sVCAM-1) in blood serum for essential hypertensive patients and essential hypertensive patients complicated with diabetes mellitus.Methods Seventy-five patients were divided into essential hypertension group (group B,34 cases) and essential hypertension combined with diabetes mellitus group(group C,41 cases).Thirty healthy people were chosen as normal control group.A double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was developed to test the level of TNF-α,leptin and sVCAM-1 in blood serum.Automatic blood biochemical analyzer and chemiluminescence were used respectively to detect the contents of fasting serum glucose (FPG) and fasting serum insulin (FINS) of the subjects.Insulin resistance index is estimated by homeostasis model assessment.Results ①The levels of TNF-α,leptin,sVCAM-1 and HOMA insulin resistance index (HOMA-IR) in group B and C were significantly higher than those in group A[TNF-α:(29.7 ±2.6),(32.9 ±3.8) μg/L vs (26.1 ± 2.7) μg/L; leptin:(5.9 ± 1.2),(12.8 ± 2.6) μg/L vs (3.2 ± 0.7) μg/L,sVCAM-1:(841 ±117),(947 ± 113) μg/L vs(678 ±87) μg/L,HOMA-IR:3.5 ±0.6,5.7 ±1.1 vs 1.3 ±0.5] (all P＜0.01),the indexes between group B and group C were significantly different as well(all P＜0.01).②In group B and C,the levels of TNF-α,leptin,sVCAM-1 were positively correlated with HOMA-IR (r =0.373,r =0.365,r=0.375,allP ＜0.05;r=0.518,r =0.469,r =0.674,allP ＜0.05).Conclusions ①TNF-α,leptin,sVCAM-1 are risk factors for hypertension and hypertension complicated with diabetes mellitus.②These indexes are also significantly associated with insulin resistance.
