国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2014年
1期
29-31
,共3页
无环鸟苷%炎琥宁%单纯疱疹病毒性角膜炎
無環鳥苷%炎琥寧%單純皰疹病毒性角膜炎
무배조감%염호저%단순포진병독성각막염
Acyclovir%Yanhuning%Herpes simplex keratitis
目的 探讨无环鸟苷与炎琥宁联合用药治疗单纯疱疹病毒性角膜炎(herpes simplex keratitis,HSK)的临床疗效及安全性.方法 将80例HSK患者用抽签的方法随机分至对照组与干预组.对照组采用无环鸟苷滴眼液点眼治疗,干预组在此基础上给予炎琥宁冻干粉针刺治疗.比较两组临床疗效及副反应发生率.结果 干预组治疗有效率为95％,对照组有效率75％,两组比较有统计学差异(P＜0.05).干预组患者的复发率明显低于对照组(P＜0.05).干预组的起效时间为(1.4±0.6)d、角膜溃疡愈合时间为(5.4±0.8)d、充血消退时间为(6.6±1.1)d、刺激症状消失时间为(6.3±0.7)d均短于对照组(P＜0.05).干预组的不良反应发生率为12.50％明显低于对照组(P＜0.05).结论 无环鸟苷与炎琥宁联合用药治疗HSK临床疗效显著,复发率低,可加以推广及应用.
目的 探討無環鳥苷與炎琥寧聯閤用藥治療單純皰疹病毒性角膜炎(herpes simplex keratitis,HSK)的臨床療效及安全性.方法 將80例HSK患者用抽籤的方法隨機分至對照組與榦預組.對照組採用無環鳥苷滴眼液點眼治療,榦預組在此基礎上給予炎琥寧凍榦粉針刺治療.比較兩組臨床療效及副反應髮生率.結果 榦預組治療有效率為95％,對照組有效率75％,兩組比較有統計學差異(P＜0.05).榦預組患者的複髮率明顯低于對照組(P＜0.05).榦預組的起效時間為(1.4±0.6)d、角膜潰瘍愈閤時間為(5.4±0.8)d、充血消退時間為(6.6±1.1)d、刺激癥狀消失時間為(6.3±0.7)d均短于對照組(P＜0.05).榦預組的不良反應髮生率為12.50％明顯低于對照組(P＜0.05).結論 無環鳥苷與炎琥寧聯閤用藥治療HSK臨床療效顯著,複髮率低,可加以推廣及應用.
목적 탐토무배조감여염호저연합용약치료단순포진병독성각막염(herpes simplex keratitis,HSK)적림상료효급안전성.방법 장80례HSK환자용추첨적방법수궤분지대조조여간예조.대조조채용무배조감적안액점안치료,간예조재차기출상급여염호저동간분침자치료.비교량조림상료효급부반응발생솔.결과 간예조치료유효솔위95％,대조조유효솔75％,량조비교유통계학차이(P＜0.05).간예조환자적복발솔명현저우대조조(P＜0.05).간예조적기효시간위(1.4±0.6)d、각막궤양유합시간위(5.4±0.8)d、충혈소퇴시간위(6.6±1.1)d、자격증상소실시간위(6.3±0.7)d균단우대조조(P＜0.05).간예조적불량반응발생솔위12.50％명현저우대조조(P＜0.05).결론 무배조감여염호저연합용약치료HSK림상료효현저,복발솔저,가가이추엄급응용.
Objective To explore the clinical efficacy and safety of acyclovir combined with Yanhuning to treat herpes simplex keratitis(HSK).Methods A total of 80 patients with HSK were included in our study.They were divided into control group and treatment group randomly.Acyclovir eye drops treatment was used in control group,while treatment group received lyophilized powder Yanhuning acupuncture treatment on the base of acyclovir eye drops treatment.Clinical efficacy and side effects were compared.Results The response rate in treatment group was significantly higher than that in control group (95％ vs 75％,P ＜ 0.05),while the relapse rate statistically lower in treatment group than control group (P ＜ 0.05).The time from get treatment to produce effectiveness and keratohelcosis recovery was 1.4 ± 0.6d and 5.4 ± 0.8d in treatment group which were significantly shorter than that in control group.In treatment group,keratohelcosis healed in 5.4 ± 0.8 days,hyperaemia faded in 6.6 ± 1.1 days,stimulus symptoms disappeared within 6.3 ± 0.7 days,which were also statistically shorter in treatment group than control group.The side effect rate was 12.5％ in treatment group,which is lower than control group(P ＜0.05).Conclusions Acyclovi combined with Yanhuning is efficiency and safety in treating HSK.
