CAJ | 학술논문

目的:探究超声心动图肺血管阻力(pulmonary vascular resistance,PVR)在预测系统性红斑狼疮(systemic lupus erythematosus,SLE)患者右心功能障碍中的价值.方法:将43例SLE患者根据超声心动图肺动脉收缩压(PASP)检测结果分为两组:A组(无肺动脉高压组,PASP≤30 mmHg,n=23)；B组(肺动脉高压组,PASP＞30 mmHg,n=20).所有患者均接受相应实验室检查,采用超声心动图检测患者PVR及右室面积变化分数(fractional area change,FAC),并分析临床、实验室及心脏超声各项指标与右心功能减退的关系.结果:两组SLE患者中,12项超声指标差异具有统计学意义(P＜0.01).将FAC＜35％作为应变量,经年龄和性别调整后行多元Logistic回归分析发现,FAC的降低仅与PVR相关[风险指数(odds ratio)=9.85,P=0.04].受试者工作特征曲线(receiver operator characteristic curve,ROC)分析显示,PVR＞ 1.45 wood单位预测FAC＜35％的曲线下面积(area under the curve,AUC)为0.91 (P＜0.001),敏感性为92％,特异性为68％.结论:PVR预测右心功能障碍的准确性及敏感性优于PASP,是评估SLE患者疗效和预后的新的预测因子.
목적:탐구초성심동도폐혈관조력(pulmonary vascular resistance,PVR)재예측계통성홍반랑창(systemic lupus erythematosus,SLE)환자우심공능장애중적개치.방법:장43례SLE환자근거초성심동도폐동맥수축압(PASP)검측결과분위량조:A조(무폐동맥고압조,PASP≤30 mmHg,n=23)；B조(폐동맥고압조,PASP＞30 mmHg,n=20).소유환자균접수상응실험실검사,채용초성심동도검측환자PVR급우실면적변화분수(fractional area change,FAC),병분석림상、실험실급심장초성각항지표여우심공능감퇴적관계.결과:량조SLE환자중,12항초성지표차이구유통계학의의(P＜0.01).장FAC＜35％작위응변량,경년령화성별조정후행다원Logistic회귀분석발현,FAC적강저부여PVR상관[풍험지수(odds ratio)=9.85,P=0.04].수시자공작특정곡선(receiver operator characteristic curve,ROC)분석현시,PVR＞ 1.45 wood단위예측FAC＜35％적곡선하면적(area under the curve,AUC)위0.91 (P＜0.001),민감성위92％,특이성위68％.결론:PVR예측우심공능장애적준학성급민감성우우PASP,시평고SLE환자료효화예후적신적예측인자.