中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
1期
33-35
,共3页
林艳%杨佳莹%曹勇%郑长青
林豔%楊佳瑩%曹勇%鄭長青
림염%양가형%조용%정장청
溃疡性结肠炎%老年人%内镜检查
潰瘍性結腸炎%老年人%內鏡檢查
궤양성결장염%노년인%내경검사
Ulcerative colitis%Elderly%Colonoscopy
目的 探讨老年溃疡性结肠炎(UC)患者与非老年患者临床特点的差异,为老年UC的临床诊治提供经验.方法 回顾性分析我院2009年1月至2012年10月收治的204例住院UC患者的临床及内镜资料,通过自建量表建立数据库,以发病60岁作为分组标准,分为老年组(发病年龄≥60岁)和非老年组(发病年龄＜60岁),比较两组在临床表现、实验室检查、内镜检查等方面是否存在差异.结果 204例UC患者中,老年患者33例(16.2％,33/204),非老年患者171例(83.8％,171/204),发病高峰年龄为30～39岁.在老年UC患者中,主要临床表现、肠外表现、并发症、临床严重程度及内镜下分级与非老年组比较差异均无统计学意义(P均＞0.05),但腹胀(36.4％与14.6％)、便秘(9.1％与1.2％)、排便困难(6.1％与0.6％)、菌群失调(66.7％与48.0％)、低钾血症(45.5％与14.0％)、低蛋白血症(36.4％与20.5％)与非老年组比较差异均有统计学意义(x2值分别为8.808、7.260、5.724、3.876、17.660、3.942,P均＜0.05).老年组患者结肠病变范围多局限于脾曲以下,与非老年组相比差异有统计学意义(P =0.044).结论 老年UC患者临床表现及疾病严重程度与非老年患者相似,但病变范围多局限于脾曲以下,易合并低钾血症、低蛋白血症、肠道菌群失调,应予以重视.
目的 探討老年潰瘍性結腸炎(UC)患者與非老年患者臨床特點的差異,為老年UC的臨床診治提供經驗.方法 迴顧性分析我院2009年1月至2012年10月收治的204例住院UC患者的臨床及內鏡資料,通過自建量錶建立數據庫,以髮病60歲作為分組標準,分為老年組(髮病年齡≥60歲)和非老年組(髮病年齡＜60歲),比較兩組在臨床錶現、實驗室檢查、內鏡檢查等方麵是否存在差異.結果 204例UC患者中,老年患者33例(16.2％,33/204),非老年患者171例(83.8％,171/204),髮病高峰年齡為30～39歲.在老年UC患者中,主要臨床錶現、腸外錶現、併髮癥、臨床嚴重程度及內鏡下分級與非老年組比較差異均無統計學意義(P均＞0.05),但腹脹(36.4％與14.6％)、便祕(9.1％與1.2％)、排便睏難(6.1％與0.6％)、菌群失調(66.7％與48.0％)、低鉀血癥(45.5％與14.0％)、低蛋白血癥(36.4％與20.5％)與非老年組比較差異均有統計學意義(x2值分彆為8.808、7.260、5.724、3.876、17.660、3.942,P均＜0.05).老年組患者結腸病變範圍多跼限于脾麯以下,與非老年組相比差異有統計學意義(P =0.044).結論 老年UC患者臨床錶現及疾病嚴重程度與非老年患者相似,但病變範圍多跼限于脾麯以下,易閤併低鉀血癥、低蛋白血癥、腸道菌群失調,應予以重視.
목적 탐토노년궤양성결장염(UC)환자여비노년환자림상특점적차이,위노년UC적림상진치제공경험.방법 회고성분석아원2009년1월지2012년10월수치적204례주원UC환자적림상급내경자료,통과자건량표건립수거고,이발병60세작위분조표준,분위노년조(발병년령≥60세)화비노년조(발병년령＜60세),비교량조재림상표현、실험실검사、내경검사등방면시부존재차이.결과 204례UC환자중,노년환자33례(16.2％,33/204),비노년환자171례(83.8％,171/204),발병고봉년령위30～39세.재노년UC환자중,주요림상표현、장외표현、병발증、림상엄중정도급내경하분급여비노년조비교차이균무통계학의의(P균＞0.05),단복창(36.4％여14.6％)、편비(9.1％여1.2％)、배편곤난(6.1％여0.6％)、균군실조(66.7％여48.0％)、저갑혈증(45.5％여14.0％)、저단백혈증(36.4％여20.5％)여비노년조비교차이균유통계학의의(x2치분별위8.808、7.260、5.724、3.876、17.660、3.942,P균＜0.05).노년조환자결장병변범위다국한우비곡이하,여비노년조상비차이유통계학의의(P =0.044).결론 노년UC환자림상표현급질병엄중정도여비노년환자상사,단병변범위다국한우비곡이하,역합병저갑혈증、저단백혈증、장도균군실조,응여이중시.
Objective To investigate the clinical characteristics between elderly and non-elderly patients with ulcerative colitis (UC) in order to provide the base for diagnosis and management of the disease.Methods Two hundred and four patients with UC admitted to Shengjing Hospital from January 2009 to December 2011 were enrolled in this study.The patients were divided into elderly group (≥60 years of age) and non-elderly group(＜ 60 years of age).The clinical manifestation,laboratory examination indices and endoscopic feature were recorded and analyzed.Results Among the 204 cases with UC,33 (16.2％,33/204) were elderly patients,and 171 (83.8％,171/204) were non-elderly patients.Onset peak of U C was ranged from 30-39 years old.There was no significant difference in terms of other indices of clinical presentations,extraintestinal manifestations,complications,clinical and endoscopic score between two groups.The rate of abdominal distension,constipation,difficult defecation,alteration of intestinal flora,hypokalemia and hypoproteinemia in elderly group were 36.4％,9.1％,6.1％,66.7％,45.5％,36.4％ respectively,higher than that in in nonelderly group (14.6％,1.2％,0.6％,48.0％,14.0％,20.5％ respectively),and there was significant differences between groups (x2 =8.808,7.260,5.724,3.876,17.660 and 3.942 respectively,P ＜ 0.05).Endoscopic examination revealed that the colonic lesion parts in elderly patients was limited in left-side colon and protosigmoid,which was different from that of no-elderly group (P =0.044).Conclusion The elderly patients showed a similar clinical manifestation with non-elderly patients.However,the colonic lesion parts in elder group was limited to left-side colon and protosigmoid.They also had the higher rate of hypoproteinemia,hypokalemia and alteration of intestinal flora,which needed to pay more attention.
