CAJ | 학술논문

目的探讨非糖尿病腹膜透析患者糖化血红蛋白(HbAlc)水平与颈动脉内中膜厚度(CIMT)的相关性,明确HbAlc是否为颈动脉硬化的预测因子.方法选择非糖尿病腹膜透析的成年患者42例[平均年龄(48.2± 12.3)岁,男性21例],超声检测CIMT,按CIMT厚度分为两组:CIMT正常组(CIMT＜ 0.9 mm)和CIMT增厚组(CIMT≥0.9 mm).使用Spearman秩相关和多重线性回归分析CIMT的影响因素.结果非糖尿病腹膜透析患者CIMT与年龄、餐后2h血糖、LDL-C、TG、TC、HbAlc呈正相关(r=0.355、0.373、0.416、0.345、0.351、0.456,均P＜0.05),而HbAlc对CIMT的影响最大(β=0.459).结论在非糖尿病腹膜透析患者中,HbAlc水平与CIMT正相关,HbAlc可能是颈动脉硬化的预测因子.
목적 탐토비당뇨병복막투석환자당화혈홍단백(HbAlc)수평여경동맥내중막후도(CIMT)적상관성,명학HbAlc시부위경동맥경화적예측인자.방법 선택비당뇨병복막투석적성년환자42례[평균년령(48.2± 12.3)세,남성21례],초성검측CIMT,안CIMT후도분위량조:CIMT정상조(CIMT＜ 0.9 mm)화CIMT증후조(CIMT≥0.9 mm).사용Spearman질상관화다중선성회귀분석CIMT적영향인소.결과 비당뇨병복막투석환자CIMT여년령、찬후2h혈당、LDL-C、TG、TC、HbAlc정정상관(r=0.355、0.373、0.416、0.345、0.351、0.456,균P＜0.05),이HbAlc대CIMT적영향최대(β=0.459).결론 재비당뇨병복막투석환자중,HbAlc수평여CIMT정상관,HbAlc가능시경동맥경화적예측인자.
Objective To investigate the correlation between glycosylated hemoglobin (HbAlc) and carotid intima-media thickness (CIMT) in non-diabetic peritoneal dialysis patients.Methods Forty-two non-diabetic peritoneal dialysis adult patients were enrolled in this study [mean age was (48.2± 12.3) years,50％ was male].CIMT was determined by carotid ultrasound.Patients were divided into two groups according to CIMT:CIMT normal group (CIMT ＜ 0.9 mm) and CIMT thickening group (CIMT≥0.9 mm).HbAlc,2-hour postprandial blood glucose (2hPBG) and other factors of the patients were analyzed with Spearman rank correlation and multiple linear regression.Results CIMT was correlated with age,2hPBG,LDL-C,TG,TC,HbA1c in non-diabetic peritoneal dialysis patients (r =0.355,0.373,0.416,0.345,0.351,0.456,all P ＜ 0.05).Multiple linear regression showed that HbA1c was the most powerful influence factor of CIMT(β =0.459).Conclusion HbA1c level is positively correlated with CIMT and may be a predictor of carotid atherosclerosis in non-diabetic peritoneal dialysis patients.