CAJ | 학술논문

目的探讨子宫内膜癌国际妇产科联盟2009年(FIGO 2009)分期中Ⅰ期的临床意义.方法收集北京大学人民医院1998年12月至2009年12月间收治的FIGO 2009分期为Ⅰ期,随访资料较完整且行全面分期手术的子宫内膜癌患者233例,FIGO 2009分期中将FIGO 1988分期中的Ⅰ a期及Ⅰb期归为Ⅰa期,Ⅰc期归为Ⅰb期,将子宫颈腺体受累(Ⅱa期)归为Ⅰ期并根据其肌层浸润深度确定归为Ⅰa期或者Ⅰb期,取消FIGO 1988分期中的Ⅰ c期.对照FIGO 1988分期,回顾性分析与FIGO 1988分期相关的临床病理因素.结果 233例FIGO 2009分期为Ⅰ期的子宫内膜癌患者中,FIGO 1988分期为Ⅰa期41例、Ⅰb期146例、Ⅰc期29例、Ⅱa期17例.对FIGO 1988分期中Ⅰa期、Ⅰb期进行分析显示,病理分级、病理类型、脉管内癌栓、ER、PR表达、术后化疗及术后放化疗与Ⅰa期、Ⅰb期分期均无明显相关性(P均＞0.05);而肌层浸润深度与Ⅰ a期、Ⅰb期分期密切相关(P=0.000).对FIGO 1988分期中Ⅰ期、Ⅱa期进行分析显示,病理分级、病理类型、脉管内癌栓、肌层浸润、ER、PR表达、术后化疗及术后放化疗与Ⅰ期、Ⅱa期分期均无明显相关性(P均＞0.05).结论子宫内膜癌FIGO 2009新分期中的Ⅰ期较FIGO 1988分期中的Ⅰ期和Ⅱa期更符合患者的实际临床状况.
목적 탐토자궁내막암국제부산과련맹2009년(FIGO 2009)분기중Ⅰ기적림상의의.방법 수집북경대학인민의원1998년12월지2009년12월간수치적FIGO 2009분기위Ⅰ기,수방자료교완정차행전면분기수술적자궁내막암환자233례,FIGO 2009분기중장FIGO 1988분기중적Ⅰ a기급Ⅰb기귀위Ⅰa기,Ⅰc기귀위Ⅰb기,장자궁경선체수루(Ⅱa기)귀위Ⅰ기병근거기기층침윤심도학정귀위Ⅰa기혹자Ⅰb기,취소FIGO 1988분기중적Ⅰ c기.대조FIGO 1988분기,회고성분석여FIGO 1988분기상관적림상병리인소.결과 233례FIGO 2009분기위Ⅰ기적자궁내막암환자중,FIGO 1988분기위Ⅰa기41례、Ⅰb기146례、Ⅰc기29례、Ⅱa기17례.대FIGO 1988분기중Ⅰa기、Ⅰb기진행분석현시,병리분급、병리류형、맥관내암전、ER、PR표체、술후화료급술후방화료여Ⅰa기、Ⅰb기분기균무명현상관성(P균＞0.05);이기층침윤심도여Ⅰ a기、Ⅰb기분기밀절상관(P=0.000).대FIGO 1988분기중Ⅰ기、Ⅱa기진행분석현시,병리분급、병리류형、맥관내암전、기층침윤、ER、PR표체、술후화료급술후방화료여Ⅰ기、Ⅱa기분기균무명현상관성(P균＞0.05).결론 자궁내막암FIGO 2009신분기중적Ⅰ기교FIGO 1988분기중적Ⅰ기화Ⅱa기경부합환자적실제림상상황.
Objective To discuss the clinical significance of Federation International of Gynecology and Obstetrics (FIGO) 2009 staging Ⅰ and its prognostic related factors in endometrial carcinoma.Methods A retrospective analysis was carried out on 233 cases with FIGO 2009 staging Ⅰ endometrial carcinoma who were admitted to Department of Obstetrics and Gynecology,Peking University People's Hospital from Dec.1998 to Dec.2009 and were carried with complete staging operation then compared with FIGO 1988 staging.All follow-up data were complete.Results Of the 233 cases,including FIGO 1988 staging Ⅰ a 41 cases,Ⅰ b 146 cases,Ⅰ c 29 cases and Ⅱ a 17 cases.The univariate analysis revealed that there were no significant difference between staging Ⅰ a and Ⅰ b group in histological grade,pathological type,intravascular vessel cancer embolus,the expression of ER,PR,postoperative chemotherapy or postoperative chemoradiotherapy (all P＞0.05).The univariate analysis revealed that there were no significant difference between staging Ⅰ and Ⅱ a group in histological grade,pathological type,intravascular vessel cancer embolus,the depth of myometrial invasion,the expression of ER and PR postoperative chemotherapy or postoperative chemoradiotherapy (all P＞0.05).Conclusion FIGO 2009 staging Ⅰ in endometrial carcinoma is more consistent with the patient's clinical status than that in FIGO 1988 stage Ⅰ and Ⅱa.