中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
8期
1145-1147
,共3页
灼口综合征%白细胞介素%肿瘤坏死因子
灼口綜閤徵%白細胞介素%腫瘤壞死因子
작구종합정%백세포개소%종류배사인자
Burning Mouth Syndrome(BMS)%Interleukin%Tumor Necrosis Factor
目的 探讨灼口综合征患者治疗前后血清IL-2、6和TNF-α水平的变化及疗效.方法 选择灼口综合征患者50例(病例组)予以氯硝西泮片2 mg,1次/d;氟西汀胶囊20 mg,1次/d,连用4周.观察并比较治疗前和治疗4周后血浆细胞因子IL-2、6和TNF-α水平的变化,并进行临床疗效观察.另选择同期在体检中心体检的健康者30例作为对照组.结果 治疗前病例组血清IL-2、6和TNF-α水平明显高于对照组(=4.31、2.97、3.84,均P＜0.01).治疗4周后,患者血清IL-2、6和TNF-α水平均较治疗前明显下降(t=2.88、2.34、3.21,P＜0.05或P＜0.01).治疗4周后病例组治愈6例、显效14例和有效24例,临床总有效率高达88.0％ (44/50).结论 灼口综合征患者存在血清IL-2、6和TNF-α水平的异常升高,可作为灼口综合征早期诊断的敏感血清学指标.血清IL-2、6和TNF-α水平的变化可作为灼口综合征患者治疗疗效随访和预后观察的指标.
目的 探討灼口綜閤徵患者治療前後血清IL-2、6和TNF-α水平的變化及療效.方法 選擇灼口綜閤徵患者50例(病例組)予以氯硝西泮片2 mg,1次/d;氟西汀膠囊20 mg,1次/d,連用4週.觀察併比較治療前和治療4週後血漿細胞因子IL-2、6和TNF-α水平的變化,併進行臨床療效觀察.另選擇同期在體檢中心體檢的健康者30例作為對照組.結果 治療前病例組血清IL-2、6和TNF-α水平明顯高于對照組(=4.31、2.97、3.84,均P＜0.01).治療4週後,患者血清IL-2、6和TNF-α水平均較治療前明顯下降(t=2.88、2.34、3.21,P＜0.05或P＜0.01).治療4週後病例組治愈6例、顯效14例和有效24例,臨床總有效率高達88.0％ (44/50).結論 灼口綜閤徵患者存在血清IL-2、6和TNF-α水平的異常升高,可作為灼口綜閤徵早期診斷的敏感血清學指標.血清IL-2、6和TNF-α水平的變化可作為灼口綜閤徵患者治療療效隨訪和預後觀察的指標.
목적 탐토작구종합정환자치료전후혈청IL-2、6화TNF-α수평적변화급료효.방법 선택작구종합정환자50례(병례조)여이록초서반편2 mg,1차/d;불서정효낭20 mg,1차/d,련용4주.관찰병비교치료전화치료4주후혈장세포인자IL-2、6화TNF-α수평적변화,병진행림상료효관찰.령선택동기재체검중심체검적건강자30례작위대조조.결과 치료전병례조혈청IL-2、6화TNF-α수평명현고우대조조(=4.31、2.97、3.84,균P＜0.01).치료4주후,환자혈청IL-2、6화TNF-α수평균교치료전명현하강(t=2.88、2.34、3.21,P＜0.05혹P＜0.01).치료4주후병례조치유6례、현효14례화유효24례,림상총유효솔고체88.0％ (44/50).결론 작구종합정환자존재혈청IL-2、6화TNF-α수평적이상승고,가작위작구종합정조기진단적민감혈청학지표.혈청IL-2、6화TNF-α수평적변화가작위작구종합정환자치료료효수방화예후관찰적지표.
Objective To discuss changes and curative effect of serum interleukin-2 and 6 and tumor necrosis factor-α (TNF-α) of burning mouth syndrome (BMS) patients before and after medical treatment.Methods 50 cases of BMS patients were selected as case group,and who were given Clonazepam tablets (2mg) and Fluoxetine capsules (20 mg) one time daily for 4 weeks.Observe and compare the changes of serum IL-2 and 6,and TNF-αof patients in two groups before and after 4 weeks' medical treatment,and proceeded with the clinical curative effect observation.Moreover,30 cases of healthy subjects who just took the physical examination in medical examination center(MEC) at that moment was the control group.Results The serum IL-2 and IL-6,and TNF-αlevels of patients in case group before medical treatment was obviously higher than those in control group (t =4.31,2.97,3.84,all P ＜0.01).After 4 weeks' medical treatment,serum IL-2 and IL-6,and TNF-αlevels of patients had obviously declined than before (t =2.88,2.34,3.21,P ＜ 0.05 or P ＜ 0.01).After 4 weeks' medical treatment,there were 6 cured cases,14 cases with significant effect,and 24 cases with curative effect,and the total clinical efficiency reaches 88.0％ (44/50).Conclusion BMS patients have abnormal elevation of serum IL-2 and 6,and TNF-α,which may be the sensitive serological indicators of the early diagnosis of BMS.The changes of serum IL-2 and IL-6,and TNF-α levels may be the index of follow-up curative effect and prognosis observation.
