中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
970-972
,共3页
肺癌根治术%右美托咪定%认知功能
肺癌根治術%右美託咪定%認知功能
폐암근치술%우미탁미정%인지공능
Lung resection%Dexmedetomidine%Cognitive function
目的 探讨右美托咪定对老年肺癌根治术患者苏醒质量和术后认知功能的影响.方法 选择50例美国麻醉医师协会Ⅰ～Ⅱ级肺癌根治术患者,均在复合麻醉下手术,根据随机数字表法分为研究组和对照组,各25例.研究组在诱导前20 min静脉匀速泵注右美托咪定1μg/kg,诱导后调整速率至0.3 μg/(kg·h),术毕前30 min停止输注;对照组静脉泵注同等剂量的0.9％氯化钠注射液.观察2组患者麻醉苏醒质量和术后认知功能情况.结果 研究组术后呛咳和躁动评分明显低于对照组[(2.4±0.7)分比(2.8±0.7)分,(1.6±0.5)分比(2.0±0.6)分,均P＜0.05],呼吸恢复时间、拔管时间和苏醒时间与对照组比较差异无统计学意义[(11.2±1.6) min比(10.4±1.5)min,(14.7±2.8) min比(13.3±3.4)min,(14.9±2.9) min比(14.1±2.9),均P＞0.05].2组术前和术后48 h简易精神状态检查量表评分差异无统计学意义(P＞0.05),研究组术后12、24 h简易精神状态检查量表评分明显高于对照组[术后12、24 h分别为(25.9±1.2)分比(24.2 ±1.3)分,(28.0±0.8)分比(26.7±1.0)分,均P＜0.05).结论 右美托咪定可明显改善老年肺癌根治术患者苏醒质量和术后早期认知功能.
目的 探討右美託咪定對老年肺癌根治術患者囌醒質量和術後認知功能的影響.方法 選擇50例美國痳醉醫師協會Ⅰ～Ⅱ級肺癌根治術患者,均在複閤痳醉下手術,根據隨機數字錶法分為研究組和對照組,各25例.研究組在誘導前20 min靜脈勻速泵註右美託咪定1μg/kg,誘導後調整速率至0.3 μg/(kg·h),術畢前30 min停止輸註;對照組靜脈泵註同等劑量的0.9％氯化鈉註射液.觀察2組患者痳醉囌醒質量和術後認知功能情況.結果 研究組術後嗆咳和躁動評分明顯低于對照組[(2.4±0.7)分比(2.8±0.7)分,(1.6±0.5)分比(2.0±0.6)分,均P＜0.05],呼吸恢複時間、拔管時間和囌醒時間與對照組比較差異無統計學意義[(11.2±1.6) min比(10.4±1.5)min,(14.7±2.8) min比(13.3±3.4)min,(14.9±2.9) min比(14.1±2.9),均P＞0.05].2組術前和術後48 h簡易精神狀態檢查量錶評分差異無統計學意義(P＞0.05),研究組術後12、24 h簡易精神狀態檢查量錶評分明顯高于對照組[術後12、24 h分彆為(25.9±1.2)分比(24.2 ±1.3)分,(28.0±0.8)分比(26.7±1.0)分,均P＜0.05).結論 右美託咪定可明顯改善老年肺癌根治術患者囌醒質量和術後早期認知功能.
목적 탐토우미탁미정대노년폐암근치술환자소성질량화술후인지공능적영향.방법 선택50례미국마취의사협회Ⅰ～Ⅱ급폐암근치술환자,균재복합마취하수술,근거수궤수자표법분위연구조화대조조,각25례.연구조재유도전20 min정맥균속빙주우미탁미정1μg/kg,유도후조정속솔지0.3 μg/(kg·h),술필전30 min정지수주;대조조정맥빙주동등제량적0.9％록화납주사액.관찰2조환자마취소성질량화술후인지공능정황.결과 연구조술후창해화조동평분명현저우대조조[(2.4±0.7)분비(2.8±0.7)분,(1.6±0.5)분비(2.0±0.6)분,균P＜0.05],호흡회복시간、발관시간화소성시간여대조조비교차이무통계학의의[(11.2±1.6) min비(10.4±1.5)min,(14.7±2.8) min비(13.3±3.4)min,(14.9±2.9) min비(14.1±2.9),균P＞0.05].2조술전화술후48 h간역정신상태검사량표평분차이무통계학의의(P＞0.05),연구조술후12、24 h간역정신상태검사량표평분명현고우대조조[술후12、24 h분별위(25.9±1.2)분비(24.2 ±1.3)분,(28.0±0.8)분비(26.7±1.0)분,균P＜0.05).결론 우미탁미정가명현개선노년폐암근치술환자소성질량화술후조기인지공능.
Objective To investigate the effects of dexmedetomidine on the quality of post-anesthesia recovery and postrperativecognitive dysfunction in elderly patients after lung resection.Methods Fifty elderly patients had lung resection.American Society of Anesthesiologists Ⅰ-Ⅱ and intravenous anesthesia combined with inhalation anesthesia were randomly divided into study group and control group according to the random number table,with 25 cases in each group.Dexmedetomidine 1 μg/kg was infused within 20 min before induction in study group,then it was adjusted to the rate of 0.3 μg/(kg · h) after induction.The infusion of dexmedetomidine was stopped 30 min before surgery completed.The control group received intravenous infusion of saline.The quality of post-anesthesia recovery and postoperative cognitive dysfunction were observed in two groups.Results The scores of cough and agitation in study group were significantly lower than those in the control group [(2.4 ± 0.7) scores vs (2.8 ± 0.7) scores,(1.6 ± 0.5) scores vs (2.0 ± 0.6) scores,P ＜ 0.05].There were no significantly differences in breathing recovery time,extubation time and recovery time in two goups(P ＞ 0.05).There was no significant difference in Mini-Mental State Examination (MMSE) score in two groups before surgery and postoperative 48 h(P ＞0.05).MMSE scores at 12 h,24 h after operation in study group were significantly higher than those in control group [(25.9 ± 1.2) scores vs (24.2 ± 1.3) scores and (28.0 ± 0.8) scores vs (26.7 ± 1.0) scores,P ＜0.05].Conclusion Dexmedetomidine can significantly improve the quality of post-anesthesia recovery and early postoperative cognitive dysfunction.
