CAJ | 학술논문

针对乳腺癌HER-2受体胞外结合区的靶点治疗成为当今研究的热点。小分子多肽、HER-2胞外结合区的单抗药物及其与蛋白毒素、放射性核素，化疗药物的偶联物即免疫偶联物既能增强药物的有效性，又可减少对正常组织的毒害。HER-2胞外区肽疫苗可有效预防HER-2高表达乳腺癌的生长。本文将对乳腺癌HER-2胞外区靶向阻断治疗的研究进行综述，为相应的临床应用提供参考。
침대유선암HER-2수체포외결합구적파점치료성위당금연구적열점。소분자다태、HER-2포외결합구적단항약물급기여단백독소、방사성핵소，화료약물적우련물즉면역우련물기능증강약물적유효성，우가감소대정상조직적독해。HER-2포외구태역묘가유효예방HER-2고표체유선암적생장。본문장대유선암HER-2포외구파향조단치료적연구진행종술，위상응적림상응용제공삼고。
The target therapeutic agents of HER-2 extracellular ligand-binding domain have become the core of breast cancer research. A small peptide molecule and an anti-HER2 extracellular domain monoclonal antibody conjugated with protein toxins, radioisotopes, and chemotherapeutic drugs (immunoconjugate) can improve efficacy and reduce systemic toxicity. Vaccines based on HER-2 extracellular region should protect patients from HER-2-overexpressing breast cancer growth. In this review, studies on targeted-block therapies of the HER-2 extracellular ligand-binding domain in breast cancer were discussed to provide references for clinical applications.