CAJ | 학술논문

乏氧现象广泛存在于实体肿瘤中。乏氧诱导因子-1α（hypoxia inducible factor 1α，HIF-1α）通过参与多种靶基因的转录调控影响肿瘤细胞的能量代谢、增殖和凋亡，使细胞及组织产生一系列反应以适应缺氧环境，同时促进肿瘤血管形成，也增加肿瘤自身的侵袭性及对放化疗的抵抗性。以HIF-1α为靶点的治疗将可能成为肿瘤治疗的重要手段。
핍양현상엄범존재우실체종류중。핍양유도인자-1α（hypoxia inducible factor 1α，HIF-1α）통과삼여다충파기인적전록조공영향종류세포적능량대사、증식화조망，사세포급조직산생일계렬반응이괄응결양배경，동시촉진종류혈관형성，야증가종류자신적침습성급대방화료적저항성。이HIF-1α위파점적치료장가능성위종류치료적중요수단。
Hypoxia is a common characteristic in solid tumors. With the regulation of the transcription of multiple target genes, HIF-1αplays an important role in the energy metabolism, proliferation, and apoptosis of tumor cells. HIF-1αcontributes to the adapta-tion of tumor cells and tissue to hypoxia stress through these processes. It also promotes tumor angiogenesis and increases their inva-sive ability and the resistance to radio and chemotherapy. Cancer treatment targeting on HIF-1αis an important potential therapy.