CAJ | 학술논문

目的观察制霉菌素联合碳酸氢钠注射与氟康唑治疗口腔白色念珠菌感染临床疗效比较，为临床治疗口腔念珠菌的感染用药选择提供指导。方法将64例口腔白色念珠菌感染患者随机分为两组,制霉菌素组采用制霉菌素联合碳酸氢钠注射液(2.5%碳酸氢钠溶口腔护理后,制霉菌素研粉口腔内涂沫),氟康唑组采用氟康唑胶囊(100 mg/次,1次/d,午餐后服),5d后比较两组的效果,口腔体征改善的情况。结果制霉菌素组治疗总有效率81.25%,氟康唑组治疗总有效率87.5%,统计学分析显示两组疗效无显著差异。(P>0.05)。结论制霉菌素联合碳酸氢钠注射液与氟康唑治疗口腔白色念珠菌病疗效相近,可以根据患者经济状况、不良反应、患者耐药性等具体情况选择用药。
목적관찰제매균소연합탄산경납주사여불강서치료구강백색념주균감염림상료효비교，위림상치료구강념주균적감염용약선택제공지도。방법장64례구강백색념주균감염환자수궤분위량조,제매균소조채용제매균소연합탄산경납주사액(2.5%탄산경납용구강호리후,제매균소연분구강내도말),불강서조채용불강서효낭(100 mg/차,1차/d,오찬후복),5d후비교량조적효과,구강체정개선적정황。결과제매균소조치료총유효솔81.25%,불강서조치료총유효솔87.5%,통계학분석현시량조료효무현저차이。(P>0.05)。결론제매균소연합탄산경납주사액여불강서치료구강백색념주균병료효상근,가이근거환자경제상황、불량반응、환자내약성등구체정황선택용약。
Objective To observe the combined nystatin and fluconazole treatment of oral sodium bicarbonate injection of Candida albicans clinical ef ects of infection for the clinical treatment of oral Candida infections to guide drug choice. Methods 64 cases of oral Candida albicans infection were randomly divided into two groups, group nystatin were treated with nystatin combined with injection of sodium bicarbonate (2.5%sodium bicarbonate solution after oral care,oral smear powdered nystatin), fluconazole group were treated with fluconazole capsules (each 100 mg,1 day,after lunch service),5 days after the results were compared, signs of improvement in the oral cavity. Results nystatin group total ef ective rate was 81.25%,fluconazole treatment group 87.5%,statistical analysis showed no significant dif erence between two groups. (P>0.05). Conclusion nystatin combined sodium bicarbonate injection and treatment of oral candidiasis fluconazole similar ef icacy,based on economic status of patients,side ef ects,patient specific conditions such as choice of drug resistance drug.