CAJ | 학술논문

目的探讨和分析青年乳腺癌的临床病理学特征、C-erbB-2、ER、PR表达及其与腋窝淋巴结转移的关系。方法收集新疆医科大学附属肿瘤医院2006年1月～2012年12月收治并经手术和病理证实的青年女性乳腺癌252例，回顾性分析青年乳腺癌患者的年龄分布、临床分期、病理类型及癌蛋白 C-erbB-2（以下简称C-erbB-2）、雌激素受体（ER）、孕激素受体（PR）表达等临床生物学特征，并分析肿瘤大小、肿瘤临床分期及 C-erbB-2、ER、PR表达和腋窝淋巴结转移之间的相关性。结果青年乳腺癌占同期全部乳腺癌的8.27%（252/3048）。252例青年乳腺癌病例中，浸润性癌占93.65%（236/252）；腋窝淋巴结转移率达63.89%（161/252）；ER、PR和C-erbB-2阳性表达率分别为46.19%（97/210），47.61%（100/210）和35.43%（73/206）；全组病例中，肿瘤直径＞2㎝的病例腋窝淋巴结转移率高于肿瘤直径≤2㎝的病例（P＜0.05）；临床分期Ⅰ～Ⅱ期病例占45.24%（114/252），Ⅲ～Ⅳ期病例占54.76%（138/252）。腋窝淋巴结转移率与肿瘤临床分期相关，肿瘤分期越晚，腋窝淋巴结转移率越高（P=0.00）；而C-erbB-2表达状况与腋窝淋巴结转移也有相关，C-erbB-2表达阳性率越高，腋窝淋巴结转移率越高（P＜0.01）；但腋窝淋巴结转移率与ER和PR阳性表达率之间无明显相关性（P＞0.05）。结论青年女性乳腺癌恶性程度高，侵袭性强，病理类型以浸润性癌为主；青年女性乳腺癌肿瘤大小、临床分期、C-erbB-2表达与腋窝淋巴结转移相关；青年女性乳腺癌ER、PR表达与腋窝淋巴结转移无关。
목적탐토화분석청년유선암적림상병이학특정、C-erbB-2、ER、PR표체급기여액와림파결전이적관계。방법수집신강의과대학부속종류의원2006년1월～2012년12월수치병경수술화병리증실적청년녀성유선암252례，회고성분석청년유선암환자적년령분포、림상분기、병리류형급암단백 C-erbB-2（이하간칭C-erbB-2）、자격소수체（ER）、잉격소수체（PR）표체등림상생물학특정，병분석종류대소、종류림상분기급 C-erbB-2、ER、PR표체화액와림파결전이지간적상관성。결과청년유선암점동기전부유선암적8.27%（252/3048）。252례청년유선암병례중，침윤성암점93.65%（236/252）；액와림파결전이솔체63.89%（161/252）；ER、PR화C-erbB-2양성표체솔분별위46.19%（97/210），47.61%（100/210）화35.43%（73/206）；전조병례중，종류직경＞2㎝적병례액와림파결전이솔고우종류직경≤2㎝적병례（P＜0.05）；림상분기Ⅰ～Ⅱ기병례점45.24%（114/252），Ⅲ～Ⅳ기병례점54.76%（138/252）。액와림파결전이솔여종류림상분기상관，종류분기월만，액와림파결전이솔월고（P=0.00）；이C-erbB-2표체상황여액와림파결전이야유상관，C-erbB-2표체양성솔월고，액와림파결전이솔월고（P＜0.01）；단액와림파결전이솔여ER화PR양성표체솔지간무명현상관성（P＞0.05）。결론청년녀성유선암악성정도고，침습성강，병리류형이침윤성암위주；청년녀성유선암종류대소、림상분기、C-erbB-2표체여액와림파결전이상관；청년녀성유선암ER、PR표체여액와림파결전이무관。
Objective To explore the clinic-pathological characteristics,biological characteristics and axil ary lymph nodes metastasis routine of young patients with breast cancer and improve diagnosis and treatment. Methods The 252 cases which were treated and confirmed breast cancer by biopsy at the tumor,s hospital af iliated Xinxiang autonomic area in the period of From 2006,Jan to 2012,Oct were col ected. The clinic- biological characteristics,such as age range、clinical stage、tumor sizepathaloical type and C-erbB-2、ER、PR status of the cases and their correlation between the metastasis of axil ary lymph nodes were analyzed retrospectively. Results There were 8.27% (252/3048)of young patients among al breast cancer cases col ected during the same period. Of the young patients ,93.65%(236/252) were invasive cancer. Axil ary Lymph nodes metastasis rate were found in 63.89%(161/252)of the young patients. The positive rates of ER、PR、C-erbB-2 in young patients were 46.19%(97/210),47.61%(100/210)and 35.43% (73/206) respectively. The cases of tumor size>2㎝ had a high axil ary lymph nodes metastasis rate than the group of tumor size≤2㎝ (P<0.05). the percentage of stageⅠ~Ⅱand stageⅢ~Ⅳwas 45.24%(114/252)and 54.76%(138/252) respectively. the statistic analysis indicated that, there was a correlation between the axil ary Lymph nodes metastasis rate and the tumor stage, the more late the tumor stage,the more high axil ary Lymph nodes metastasis rate (P=0.00);Also there was a correlation between the C-erbB-2 status and the axil ary Lymph nodes metastasis rate, the more positive C-erbB-2 rate ,the more high axil ary Lymph nodes metastasis rate (P<0.01);but there were no significant correlation between the positive rates of ER,PR with the axil ary lymph nodes metastasis rate (P>0.05). Conclusion 1)Breast cancer in young women had high histological grade,the parameter of strong invasion,pathological types were mainly invasive cancer. 2)there was a correlation between the tumor size 、tumor stage and C-erbB-2 with axil ary Lymph nodes metastasis of Breast cancer in young women. 3) there were no significant correlation between the status of ER,PR with the axil ary lymph nodes metastasis of Breast cancer in young women.