CAJ | 학술논문

目的评价丝裂霉素C(MMC)和5-氟尿嘧啶（5-FU）对预防翼状胬肉术后复发的安全有效性。方法选取34例双眼初发翼状胬肉患者，随机分成两组，组1患者一只眼行翼状胬肉单纯切除术，另一只眼联合辅助使用MMC；组2患者一只眼只行翼状胬肉单纯切除术，另一只眼联合辅助使用5-FU。在术后随访中，通过卡方检验，OR值计算等统计学方法对两种药物对预防翼状胬肉术后复发的安全有效性进行评价。结果所有患者经过平均随访14.6月，我们发现，翼状胬肉单纯切除术的复发率为38%，联合使用MMC后翼状胬肉复发率为2%，联合使用5-FU后翼状胬肉复发率为29%。结论 MMC对预防翼状胬肉术后复发优于5-FU的作用。
목적평개사렬매소C(MMC)화5-불뇨밀정（5-FU）대예방익상노육술후복발적안전유효성。방법선취34례쌍안초발익상노육환자，수궤분성량조，조1환자일지안행익상노육단순절제술，령일지안연합보조사용MMC；조2환자일지안지행익상노육단순절제술，령일지안연합보조사용5-FU。재술후수방중，통과잡방검험，OR치계산등통계학방법대량충약물대예방익상노육술후복발적안전유효성진행평개。결과소유환자경과평균수방14.6월，아문발현，익상노육단순절제술적복발솔위38%，연합사용MMC후익상노육복발솔위2%，연합사용5-FU후익상노육복발솔위29%。결론 MMC대예방익상노육술후복발우우5-FU적작용。
Objective:To assess the safety and ef icacy of intraoperative mitomycin C(MMC)and 5-fluorouracil(5-FU)in the prevention of pterygium recurrence. Methods:A total of 34 patients with bilateral pterygium were recruited in this study.Al of these patients were divided into two groups randomly.The patients in group 1 underwent pterygium excision in one eye and MMC was applied as adjunctive therapy for the other eye. The patients in group 1 underwent pterygium excision in one eye and 5-FU was applied as adjunctive therapy for the other eye. Chi square test and odds ratio were used to determine significance levels. Results:The recurrence rate of MMC treated group is 2%,which is much lower than those in pterygium excision group (41%). On the contrary,there was no significant dif erence between the 5-FU treated group and the pterygium excision group. Conclusion:MMC reduce the pterygium recurrence significantly than 5-FU.