医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
17期
64-65
,共2页
蒋忠君%费新雄%黄绪群%王钢胜
蔣忠君%費新雄%黃緒群%王鋼勝
장충군%비신웅%황서군%왕강성
非小细胞肺癌%同步放化疗%复方苦参注射液
非小細胞肺癌%同步放化療%複方苦參註射液
비소세포폐암%동보방화료%복방고삼주사액
Non-smal cell lung cancer%Concurrent chemoradiotherapy%Compound kushen injection
目的观察复方苦参注射液联合同步放化疗治疗III期非小细胞肺癌的近期临床疗效和毒副作用。方法96例III期非小细胞肺癌随机分为苦参组48例,对照组48例,两组均给予同步放化疗,苦参组同步放化疗开始时加用复方苦参注射液20ml加入到250ml0.9%氯化钠溶液中,静脉滴注,1次/d,至放疗结束;将复方苦参注射液5ml加入5ml生理盐水雾化吸入,2次/d,至放疗结束。结果苦参组与对照组完全缓解率分别为16.7%、12.5%,,有效率分别为70.8%、64.6%。P>0.05。苦参组骨髓抑制、消化道反应、放射性食管炎III-IV级发生率、呼吸道感染发生率低于对照组,苦参组生活质量优于对照组,P<0.05。结论复方苦参注射液虽未能提高同步放化疗疗效,但能减轻同步放化疗引起的骨髓抑制、消化道反应、放射性食管炎、呼吸道感染发生率等毒副反应,提高生活质量。
目的觀察複方苦參註射液聯閤同步放化療治療III期非小細胞肺癌的近期臨床療效和毒副作用。方法96例III期非小細胞肺癌隨機分為苦參組48例,對照組48例,兩組均給予同步放化療,苦參組同步放化療開始時加用複方苦參註射液20ml加入到250ml0.9%氯化鈉溶液中,靜脈滴註,1次/d,至放療結束;將複方苦參註射液5ml加入5ml生理鹽水霧化吸入,2次/d,至放療結束。結果苦參組與對照組完全緩解率分彆為16.7%、12.5%,,有效率分彆為70.8%、64.6%。P>0.05。苦參組骨髓抑製、消化道反應、放射性食管炎III-IV級髮生率、呼吸道感染髮生率低于對照組,苦參組生活質量優于對照組,P<0.05。結論複方苦參註射液雖未能提高同步放化療療效,但能減輕同步放化療引起的骨髓抑製、消化道反應、放射性食管炎、呼吸道感染髮生率等毒副反應,提高生活質量。
목적관찰복방고삼주사액연합동보방화료치료III기비소세포폐암적근기림상료효화독부작용。방법96례III기비소세포폐암수궤분위고삼조48례,대조조48례,량조균급여동보방화료,고삼조동보방화료개시시가용복방고삼주사액20ml가입도250ml0.9%록화납용액중,정맥적주,1차/d,지방료결속;장복방고삼주사액5ml가입5ml생리염수무화흡입,2차/d,지방료결속。결과고삼조여대조조완전완해솔분별위16.7%、12.5%,,유효솔분별위70.8%、64.6%。P>0.05。고삼조골수억제、소화도반응、방사성식관염III-IV급발생솔、호흡도감염발생솔저우대조조,고삼조생활질량우우대조조,P<0.05。결론복방고삼주사액수미능제고동보방화료료효,단능감경동보방화료인기적골수억제、소화도반응、방사성식관염、호흡도감염발생솔등독부반응,제고생활질량。
Objective To observe the recent clinical ef icacy and side ef ects of compound kushen injection given by aerosol inhalation and intravenously in treating patients with phase III Non-smal cel lung cancer. Methods 96 patients with phase III Non-smal cel lung cancer were randomly divided into two groups: the kushen group (n=48) and the control group (n=48). Both groups were treated with concurrent chemoradiotherapy, and the kushen group was given compound kushen injection plus aerosol inhalation in addition. Results The complete response rates in the kushen group and the control group are 16.7%、12.5% respectively, and the ef ective rates are 70.8%、64.6%, and both of them has no significant dif erences (P>0.05). The side ef ects such as myelosuppression, gastrointestinal reactions, radiation esophagitis in the kushen group were significantly lower than those in the control group, and the quality of life in the kushen group were bet er than that in the control group (P<0.05) Conclusion The compound kushen injection could not improve the clinical ef icacy, but it could al eviate the side ef ects caused by concurrent chemoradiotherapy so as to improve the quality of life.