医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
17期
52-53
,共2页
徐志勇%林国和%陈定科%曹红敏%池丽敏%陈伟洪%孙一%肖鹏%方佳彦%董勇
徐誌勇%林國和%陳定科%曹紅敏%池麗敏%陳偉洪%孫一%肖鵬%方佳彥%董勇
서지용%림국화%진정과%조홍민%지려민%진위홍%손일%초붕%방가언%동용
前列腺肿瘤%放射疗法%内分泌治疗
前列腺腫瘤%放射療法%內分泌治療
전렬선종류%방사요법%내분비치료
Prostate neoplasms%Radiotherapy%Endocrine therapy
目的研究调强放疗联合内分泌治疗治疗早期高危前列腺癌的疗效及不良反应。方法42例早期高危前列腺癌预期寿命均大于5年患者，随机分为两组，调强适形放射治疗（IMRT)组18例，95%体积PTV1接受76-78Gy处方剂量，95%体积PTV2接受50Gy处方剂量；常规放疗组24例，盆腔野 DT45-50Gy，前列腺野补量20-25Gy；同步采用内分泌治疗，其中接受双侧睾丸切除术1例，其余41例接受曲普瑞林3.75mg，皮下注射，每月1次。结果中位随访14个月，随访率100%。副反应发生在调强放射治疗组与常规放疗组间无显著差异（P>0.05）。按原发肿瘤、PSA及排尿困难症状评价早期疗效，两组治疗前后变化组内差异均有显著性意义（P值＜0.05），组间差异无显著性意义（P＞0.05）。结论调强放疗比常规放疗联合内分泌治疗治疗早期高危前列腺癌早期疗效及早期不良反应无显著差异。
目的研究調彊放療聯閤內分泌治療治療早期高危前列腺癌的療效及不良反應。方法42例早期高危前列腺癌預期壽命均大于5年患者，隨機分為兩組，調彊適形放射治療（IMRT)組18例，95%體積PTV1接受76-78Gy處方劑量，95%體積PTV2接受50Gy處方劑量；常規放療組24例，盆腔野 DT45-50Gy，前列腺野補量20-25Gy；同步採用內分泌治療，其中接受雙側睪汍切除術1例，其餘41例接受麯普瑞林3.75mg，皮下註射，每月1次。結果中位隨訪14箇月，隨訪率100%。副反應髮生在調彊放射治療組與常規放療組間無顯著差異（P>0.05）。按原髮腫瘤、PSA及排尿睏難癥狀評價早期療效，兩組治療前後變化組內差異均有顯著性意義（P值＜0.05），組間差異無顯著性意義（P＞0.05）。結論調彊放療比常規放療聯閤內分泌治療治療早期高危前列腺癌早期療效及早期不良反應無顯著差異。
목적연구조강방료연합내분비치료치료조기고위전렬선암적료효급불량반응。방법42례조기고위전렬선암예기수명균대우5년환자，수궤분위량조，조강괄형방사치료（IMRT)조18례，95%체적PTV1접수76-78Gy처방제량，95%체적PTV2접수50Gy처방제량；상규방료조24례，분강야 DT45-50Gy，전렬선야보량20-25Gy；동보채용내분비치료，기중접수쌍측고환절제술1례，기여41례접수곡보서림3.75mg，피하주사，매월1차。결과중위수방14개월，수방솔100%。부반응발생재조강방사치료조여상규방료조간무현저차이（P>0.05）。안원발종류、PSA급배뇨곤난증상평개조기료효，량조치료전후변화조내차이균유현저성의의（P치＜0.05），조간차이무현저성의의（P＞0.05）。결론조강방료비상규방료연합내분비치료치료조기고위전렬선암조기료효급조기불량반응무현저차이。
Objective To investigate the side ef ect and ef icacy of intensity modulated radiotherapy combined with endocrine therapy for early high-risk prostate cancer. Methods 42 patients with early prostate cancer were col ected from Dongguan ShiLong People's Hospital.18 patients treated with intensity modulated radiotherapy and 24 patients treated with conventional radiotherapy were analyzed respectively.Both two groups were combined with endocrine therapy.One patient accepted bilateral testicular resection,and others were combined with Triptorelin simultaneously. Results There was on significant dif erence in the incidence of side ef ects between intensity modulated radiotherapy and conventional radiotherapy group (P>0.05).According to the primary tumor、PSA and dysuria symptom,there was no significant dif erence between intensity modulated radiotherapy and conventional radiotherapy group (P>0.05). Conclusions compared with conventional radiotherapy, IMRT did not increased early ef icacy and decreased the incidence of early side ef ects.
