CAJ | 학술논문

目的：探讨可逆性后部白质脑病综合征（RPLS）的病因、临床表现及影像学特征。方法分析20例RPLS患者的临床及影像学资料，总结该病的病因、临床表现及头颅MRI影像改变。结果高血压与子痫是最主要的病因，主要临床表现为头痛，痫性发作，视觉障碍，恶心、呕吐，意识状态改变，精神异常和行为改变。MRI表现：病变主要累及顶枕叶皮层，可波及额颞叶，可累及脑干、小脑、丘脑。T1WI为等或低信号改变，T2WI为高信号改变，DWI为等或略高信号改变，ADC为高信号改变。结论 RPLS的发病机制为急性大脑白质血管源性水肿。经积极治疗绝大数RPLS患者预后较好。
목적：탐토가역성후부백질뇌병종합정（RPLS）적병인、림상표현급영상학특정。방법분석20례RPLS환자적림상급영상학자료，총결해병적병인、림상표현급두로MRI영상개변。결과고혈압여자간시최주요적병인，주요림상표현위두통，간성발작，시각장애，악심、구토，의식상태개변，정신이상화행위개변。MRI표현：병변주요루급정침협피층，가파급액섭협，가루급뇌간、소뇌、구뇌。T1WI위등혹저신호개변，T2WI위고신호개변，DWI위등혹략고신호개변，ADC위고신호개변。결론 RPLS적발병궤제위급성대뇌백질혈관원성수종。경적겁치료절대수RPLS환자예후교호。
Objective To analyze the etiology, clinical features specific and characteristics of magnetic resonance image (MRI) of reversible posterior leukoencephalopathy syndrome (RPLS). Methods A retrospective analysis about clinical characteristics and MRI was performed in 20 patients with reversible posterior leukoencephalopathy syndrome, summarize the etiology, clinical manifestations and MRI. Results Hypertension and eclampsia is the most important cause of RPLS,the clinical manifestations mainly included headache,seizure disorder, visual hal ucination, nausea and vomiting, consciousness disorders, delirium and behavior change. MRI examination showed the lesions which located mainly in the occipital cortex, frontotemporal cortex, brain stem, cerebel um and thalamus;T1WI showed equal or low signal, T2WI showed high signal, DW1 showed equal or high signal and ADC showed high signal. Conclusion The etiology of RPLS is mainly acute vasogenic edema in cerebral cortex. There is bet er prognosis for most of them by timely and ef ective treatment.