CAJ | 학술논문

目的探讨免疫细胞因子白细胞介素1β（IL-1β）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）在支气管哮喘大鼠模型中的变化及作用。方法选取雄性Wistar大鼠30只，随机分为正常组（15只）和实验组（15只）：实验组大鼠予以腹腔注射卵清蛋白和氢氧化铝混悬液致敏以及卵清蛋白溶液雾化吸入激发，对正常组大鼠腹腔注射及激发均以生理盐水代替，分别于第25 d处死大鼠，检测2组外周血IL-1β、IL-6和TNF-α等免疫指标的变化。结果与正常组相比，实验组大鼠血清 IL-1β、IL-6和 TNF-α水平均升高，均具有统计学意义（P＜0.01）。结论支气管哮喘模型发作期免疫细胞因子 IL-1β、IL-6和 TNF-α的异常变化，促进了支气管哮喘进一步发展为重度哮喘
목적탐토면역세포인자백세포개소1β（IL-1β）、백세포개소6（IL-6）、종류배사인자α（TNF-α）재지기관효천대서모형중적변화급작용。방법선취웅성Wistar대서30지，수궤분위정상조（15지）화실험조（15지）：실험조대서여이복강주사란청단백화경양화려혼현액치민이급란청단백용액무화흡입격발，대정상조대서복강주사급격발균이생리염수대체，분별우제25 d처사대서，검측2조외주혈IL-1β、IL-6화TNF-α등면역지표적변화。결과여정상조상비，실험조대서혈청 IL-1β、IL-6화 TNF-α수평균승고，균구유통계학의의（P＜0.01）。결론지기관효천모형발작기면역세포인자 IL-1β、IL-6화 TNF-α적이상변화，촉진료지기관효천진일보발전위중도효천
Objective Observes interleukin-1β (IL-1β), interleukin 6 (IL-6), tumor necrosis α (TNF-α), of change in asthma in rats model, study this immune function developing process asthma. Methods Select 30 male Wistar rats, (15) were randomly divided into normal group and experimental group (15) :the experimental group Using ovalbumin and aluminum hydroxide mixed suspension and ovalbumin sensitization to solution atomization inhalation furthurly to establish hepatic, in normal group and inspired by physiological saline instead of, and 25 days after ratinterleukin-1β(IL-1β), interleukin 6 (IL-6), tumor necrosis Factor α(TNF-α), immune changes. Results Compared with normal group, experimental group, serum IL-1β, IL-6 and TNF-α levels were elevated, IL-1β significantly dif erent (P<0.01), IL-6 and TNF-α more significant dif erences (P<0.001). Conclusion Hepatocirrhosis in rats model and its disorder immune function possibly through promotes the The 2 kind of cel factor secretion, thus the promotion Hepatocirrhosis in rats model.