CAJ | 학술논문

目的探讨妥洛特罗贴剂联合孟鲁司特钠治疗儿童咳嗽变异性哮喘（CVA）的疗效和安全性。方法90例患儿随机分为治疗组和对照组。对照组为吸入性布地奈德联合盐酸丙卡特罗片剂治疗，治疗组在吸入性布地奈德基础上给予妥洛特罗贴剂和孟鲁司特钠治疗。治疗14d后，比较各组咳嗽症状评分，根据症状总积分改善比率来判断疗效，测定1s用力气容积（FEV1）、最大呼气风流速（PEF），如患者肺功能异常（FEV1和/或PEF<80%），行支气管舒张实验，肺通气功能正常行运动激发实验。结果各组间患儿一般资料比较差异无统计学意义（P>0.05），治疗组症状评分明显下降，与对照组差异有统计学意义，见效时间较对照组短（P<0.05）；治疗结束后治疗组和对照组的显效率分别为93.33%和66.67%，差异有统计学意义（P<0.05）。治疗组治疗后激发试验及舒张试验阳性比率较治疗前及对照组明显下降（P<0.05）。结论妥洛特罗贴剂联合孟鲁司特钠治疗儿童咳嗽变异性哮喘效果显著，安全可靠。
목적탐토타락특라첩제연합맹로사특납치료인동해수변이성효천（CVA）적료효화안전성。방법90례환인수궤분위치료조화대조조。대조조위흡입성포지내덕연합염산병잡특라편제치료，치료조재흡입성포지내덕기출상급여타락특라첩제화맹로사특납치료。치료14d후，비교각조해수증상평분，근거증상총적분개선비솔래판단료효，측정1s용력기용적（FEV1）、최대호기풍류속（PEF），여환자폐공능이상（FEV1화/혹PEF<80%），행지기관서장실험，폐통기공능정상행운동격발실험。결과각조간환인일반자료비교차이무통계학의의（P>0.05），치료조증상평분명현하강，여대조조차이유통계학의의，견효시간교대조조단（P<0.05）；치료결속후치료조화대조조적현효솔분별위93.33%화66.67%，차이유통계학의의（P<0.05）。치료조치료후격발시험급서장시험양성비솔교치료전급대조조명현하강（P<0.05）。결론타락특라첩제연합맹로사특납치료인동해수변이성효천효과현저，안전가고。
Objective To evaluate the ef icacy of tulobuterol tape and montelukast-na on children's cough variant asthma. Methods 90 children with cough variant astma (CVA) were randomly divided into treatment group and control groups. Based on the treatment of budesonide atomization inhalation, patients in treatment group were given to tulobuterol tape and montelukast-na,and those in control group were given to procaterol hydrochloride. After 14 days therapy,evaluation was conducted to the degree of cough,the ef icacy based on the rate of improved symptom score,forced expiratory volume in 1 second (FEV1),peak expiratory flow (PEF),bronchial diastolic test and sports provocation test. Results Dif erences of general data among the groups were not significant.For the treatment group,the symptom of cough was obviously al eviated. The time for relieving cough was significantly shorter than that in control group (P<0.05). After 14 days treatment,the ef ective rate of treatment group and control groups were 93.33% and 66.67%.There were significant dif erences between the groups in ef ective rate (P<0.05). The FEV1,PEF and airway hyperreactivity were improved in treatment group compared with those in control groups (P<0.05).The positive rates of bronchial diastolic test and sports provocation test in treatment group after treatment were decreased significantly compared to those in control group and before treatment. Conclusions Tulobuterol tape shows dramatic ef ect with montelukast-na on CVA in children.