CAJ | 학술논문

目的评价利培酮或阿立哌唑替换奋乃静治疗精神分裂症的疗效与不良反应。方法将257例服用奋乃静治疗的分裂症患者逐渐替换为利培酮和阿立哌唑治疗，采用自然观察研究方法，对研究对象进行1年跟踪研究，评价疗效及副反应。结果治疗终点利醅酮和阿立哌唑组有效率分别为62.5%和69.8%，差异无统计学意义(P>0.05)，跟踪中其他时点(2、4、6、8个月)两组有效率差异亦无统计学意义。12个月末利培酮组和阿立哌唑组的复发率(14.3%、12.3%)、持续治疗时间(9.4±3.7月、9.6±3.7月)、复发时间(4.1±2.8月、5.2±2.7月)等差异均无统计学意义(均P>0.05)。不良反应方面，利培酮组锥体外系反应比例高于阿立哌唑组，阿立哌唑组镇静作用弱。结论替换奋乃静后，利培酮与阿立哌唑治疗精神分裂症疗效均好，利培酮组锥体外系反应发生较多，阿立哌唑组镇静作用弱。
목적평개리배동혹아립고서체환강내정치료정신분렬증적료효여불량반응。방법장257례복용강내정치료적분렬증환자축점체환위리배동화아립고서치료，채용자연관찰연구방법，대연구대상진행1년근종연구，평개료효급부반응。결과치료종점리배동화아립고서조유효솔분별위62.5%화69.8%，차이무통계학의의(P>0.05)，근종중기타시점(2、4、6、8개월)량조유효솔차이역무통계학의의。12개월말리배동조화아립고서조적복발솔(14.3%、12.3%)、지속치료시간(9.4±3.7월、9.6±3.7월)、복발시간(4.1±2.8월、5.2±2.7월)등차이균무통계학의의(균P>0.05)。불량반응방면，리배동조추체외계반응비례고우아립고서조，아립고서조진정작용약。결론체환강내정후，리배동여아립고서치료정신분렬증료효균호，리배동조추체외계반응발생교다，아립고서조진정작용약。
Objective To evaluate the ef icacy and adverse reaction of Aripirazole or risperidone in the original treatment of perphenazine. Methods 257 patients with original treatment of perphenazine assigned to Aripirazole group (n=131) or risperidone group(n=126), a 12 months fol ow up was used to evaluate the ef icacy and adverse ef ect. Results The response rates at the end of 12 months of Risperidone group and Aripirazole group were 62.5% and 69.8% respectively (P>0.05). There were no dif erence for the response rates between two groups at any other fol ow-up times.There were no dif erence between Risperidone and Aripirazole groups for the relapse rate (14.5%,12.5%,respectively),the time from response to relapse(9.5±3.8 months,9.7±3.8 months,respectively)and the time to treatment discontinuation for any reason(4.0± 2.9 months,5.1 ±2.8 months,respectively)at the end of 12 month.Aripirazole was associated with lower sedative ef ect and risperidone with more EPS (extrapyramidal syndrome). Conclusion Both Aripirazole and Risperidone were ef ective for patients in the original treatment of perphenazine.Aripirazole was associated with less sedative ef ect and risperidone with more EPS.