重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
21期
2461-2462,2465
,共3页
冯庆国%魏凯%杨万杰%王伟
馮慶國%魏凱%楊萬傑%王偉
풍경국%위개%양만걸%왕위
糖尿病 ,2型%糖尿病肾病%血管黏附蛋白-1%超敏C反应蛋白%糖化血红蛋白
糖尿病 ,2型%糖尿病腎病%血管黏附蛋白-1%超敏C反應蛋白%糖化血紅蛋白
당뇨병 ,2형%당뇨병신병%혈관점부단백-1%초민C반응단백%당화혈홍단백
diabetes mellitus,type 2%diabetic nephropathy%vascular adhesion protein-1%high-sensitivity C-reactive protein%gly-cosylated hemoglobin A-1
目的观察2型糖尿病（T2DM ）患者血管黏附蛋白-1（VAP-1）、超敏C反应蛋白（hs-CRP）水平变化，探讨其与糖尿病肾病（DN）发病关系。方法采用酶联免疫吸附法（ELISA）检测DN 组患者（40例）、T2DM 组患者（39例）血清 VAP-1、hs-CRP、生化法检测血糖（Glu）、高效液相比色法检测糖化血红蛋白（GHbA-1）水平并与健康对照组（46例）比较。结果 VAP-1、hs-CRP、Glu、GHbA-1组间差异均有统计学意义（P＜0．05），DN组VAP-1、hs-CRP水平高于 T2DM 组及健康对照组，且 T2DM 组hs-CRP水平高于健康对照组。T2DM组内VAP-1与hs-CRP、Glu水平呈正相关（r＝0．568、0．755；P＜0．05、0．01）；hs-CRP与Glu、GHbA-1水平呈正相关（r＝0．886、0．475；P＜0．01、0．05）。Glu与GHbA1呈正相关（r＝0．471；P＜0．05）。DN组内VAP-1与hs-CRP、GHbA-1、Glu水平呈正相关（r＝0．521、0．830、0．454；P＜0．05、0．01、0．05），hs-CRP与Glu呈正相关（r＝0．690；P＜0．01）。结论 T2DM患者Glu及GHbA-1水平变化对VAP-1、hs-CRP升高存在影响，高VAP-1可致微血管病发生并影响患者肾功能，VAP-1拮抗治疗是预防糖尿病并发症的重要方面。
目的觀察2型糖尿病（T2DM ）患者血管黏附蛋白-1（VAP-1）、超敏C反應蛋白（hs-CRP）水平變化，探討其與糖尿病腎病（DN）髮病關繫。方法採用酶聯免疫吸附法（ELISA）檢測DN 組患者（40例）、T2DM 組患者（39例）血清 VAP-1、hs-CRP、生化法檢測血糖（Glu）、高效液相比色法檢測糖化血紅蛋白（GHbA-1）水平併與健康對照組（46例）比較。結果 VAP-1、hs-CRP、Glu、GHbA-1組間差異均有統計學意義（P＜0．05），DN組VAP-1、hs-CRP水平高于 T2DM 組及健康對照組，且 T2DM 組hs-CRP水平高于健康對照組。T2DM組內VAP-1與hs-CRP、Glu水平呈正相關（r＝0．568、0．755；P＜0．05、0．01）；hs-CRP與Glu、GHbA-1水平呈正相關（r＝0．886、0．475；P＜0．01、0．05）。Glu與GHbA1呈正相關（r＝0．471；P＜0．05）。DN組內VAP-1與hs-CRP、GHbA-1、Glu水平呈正相關（r＝0．521、0．830、0．454；P＜0．05、0．01、0．05），hs-CRP與Glu呈正相關（r＝0．690；P＜0．01）。結論 T2DM患者Glu及GHbA-1水平變化對VAP-1、hs-CRP升高存在影響，高VAP-1可緻微血管病髮生併影響患者腎功能，VAP-1拮抗治療是預防糖尿病併髮癥的重要方麵。
목적관찰2형당뇨병（T2DM ）환자혈관점부단백-1（VAP-1）、초민C반응단백（hs-CRP）수평변화，탐토기여당뇨병신병（DN）발병관계。방법채용매련면역흡부법（ELISA）검측DN 조환자（40례）、T2DM 조환자（39례）혈청 VAP-1、hs-CRP、생화법검측혈당（Glu）、고효액상비색법검측당화혈홍단백（GHbA-1）수평병여건강대조조（46례）비교。결과 VAP-1、hs-CRP、Glu、GHbA-1조간차이균유통계학의의（P＜0．05），DN조VAP-1、hs-CRP수평고우 T2DM 조급건강대조조，차 T2DM 조hs-CRP수평고우건강대조조。T2DM조내VAP-1여hs-CRP、Glu수평정정상관（r＝0．568、0．755；P＜0．05、0．01）；hs-CRP여Glu、GHbA-1수평정정상관（r＝0．886、0．475；P＜0．01、0．05）。Glu여GHbA1정정상관（r＝0．471；P＜0．05）。DN조내VAP-1여hs-CRP、GHbA-1、Glu수평정정상관（r＝0．521、0．830、0．454；P＜0．05、0．01、0．05），hs-CRP여Glu정정상관（r＝0．690；P＜0．01）。결론 T2DM환자Glu급GHbA-1수평변화대VAP-1、hs-CRP승고존재영향，고VAP-1가치미혈관병발생병영향환자신공능，VAP-1길항치료시예방당뇨병병발증적중요방면。
Objective To investigate the changes of the serum vascular adhesion protein-1(VAP-1)and high sensitivity C reac-tive protein(hs-CRP) in diabetic nephropathy(DN) and the effects in the development of diabetic nephropathy .Methods 40 cases of DN were enrolled as the DN group ,39 cases of type 2 diabetic mellitus were enrolled as the T2DM group ,and 46 cases of healthy persons were enrolled as the control group .The levels of the serum VAP-1 and hs-CRP were tested by ELISA ,the blood glucose (Glu) was tested by autochemistry analyzer and the concentrations of glycosylated hemoglobin A-1(GHbA-1) was tested by high performance liquid chromatography(HPLC) .All the resoults were compared with that of the control group .Results the differences of the levels of VAP-1 ,hs-CRP ,Glu ,GHbA-1 in different groups were ststisticlly significant (P<0 .05) ,the levels of VAP-1 and hs-CRP were higher in DN group than that of T2DM group and the control group ,and the level of hs CRP was higher in T2DM group than that of control group .The positive correlation was found in T2DM group between VAP-1 with hs-CRP and Glu(r=0 .568 ,0 .755 ,P<0 .05 ,0 .01) ,hs-CRP with Glu and GHbA-1(r= 0 .886 ,0 .475 ,P< 0 .01 ,0 .05) ,and Glu with GHbA-1(r=0 .471 ,P<0 .05) .In DN group ,the level of VAP-1 has positive correlation with the levels of hs-CRP ,GHbA-1 ,Glu(r= 0 .521 , 0 .830 ,0 .454 ,P<0 .05 ,0 .01 ,0 .05) ,the levels of hs-CRP has positive correlation with that of Glu (r=0 .690 ,P<0 .001) .Conclu-sion the changes of the levels of Glu and GHbA-1 in patients with T2DM could affect the increase of VAP-1 and hs CRP ,high content of VAP-1 could cause microangiopathy and renal function damage .Antagonist therapy of VAP-1 is important for the pre-vention of the DM complication .
