医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
23期
382-383
,共2页
肝纤维化指标%甲胎蛋白%动态变化
肝纖維化指標%甲胎蛋白%動態變化
간섬유화지표%갑태단백%동태변화
liver cirrhosis%liver fibrosis%alpha-fetoprotein%dynamic change
目的：探讨重型肝炎患者血清肝纤维化指标及甲胎蛋白(AFP)水平的动态变化。方法：182例肝病患者应用化学发光法测定病毒性肝炎患者血清三型前胶原N端肽（PⅢNP）、Ⅳ型胶原（CⅣ）、层粘连蛋白（LN）、透明质酸（HA）、总胆汁酸(TBA)、甲胎蛋白(AFP)含量变化及AFP水平与肝功能指标的关系并比较联合检测对肝硬化临床价值。结果：慢性乙型肝炎组、肝硬化、重症肝炎组肝纤维化四项及TBA、AFP指标均明显高于在正常对照组(P<0.05～0.01)；并随疾病加重，水平增高；重型肝炎患者HA与PTA、ALB、TBIL有较好的相关性(r =-0372、-0.395、0.344，P均<0.05)；在两个指标的组合中以HA＋PⅢNP的诊断价值最高，在三个指标的组合中以HA＋PⅢNP＋CIV的诊断价值最高。结论：动态监测血清HA、PⅢP、LN和AFP水平对肝病患者的预后判断有一定意义。
目的：探討重型肝炎患者血清肝纖維化指標及甲胎蛋白(AFP)水平的動態變化。方法：182例肝病患者應用化學髮光法測定病毒性肝炎患者血清三型前膠原N耑肽（PⅢNP）、Ⅳ型膠原（CⅣ）、層粘連蛋白（LN）、透明質痠（HA）、總膽汁痠(TBA)、甲胎蛋白(AFP)含量變化及AFP水平與肝功能指標的關繫併比較聯閤檢測對肝硬化臨床價值。結果：慢性乙型肝炎組、肝硬化、重癥肝炎組肝纖維化四項及TBA、AFP指標均明顯高于在正常對照組(P<0.05～0.01)；併隨疾病加重，水平增高；重型肝炎患者HA與PTA、ALB、TBIL有較好的相關性(r =-0372、-0.395、0.344，P均<0.05)；在兩箇指標的組閤中以HA＋PⅢNP的診斷價值最高，在三箇指標的組閤中以HA＋PⅢNP＋CIV的診斷價值最高。結論：動態鑑測血清HA、PⅢP、LN和AFP水平對肝病患者的預後判斷有一定意義。
목적：탐토중형간염환자혈청간섬유화지표급갑태단백(AFP)수평적동태변화。방법：182례간병환자응용화학발광법측정병독성간염환자혈청삼형전효원N단태（PⅢNP）、Ⅳ형효원（CⅣ）、층점련단백（LN）、투명질산（HA）、총담즙산(TBA)、갑태단백(AFP)함량변화급AFP수평여간공능지표적관계병비교연합검측대간경화림상개치。결과：만성을형간염조、간경화、중증간염조간섬유화사항급TBA、AFP지표균명현고우재정상대조조(P<0.05～0.01)；병수질병가중，수평증고；중형간염환자HA여PTA、ALB、TBIL유교호적상관성(r =-0372、-0.395、0.344，P균<0.05)；재량개지표적조합중이HA＋PⅢNP적진단개치최고，재삼개지표적조합중이HA＋PⅢNP＋CIV적진단개치최고。결론：동태감측혈청HA、PⅢP、LN화AFP수평대간병환자적예후판단유일정의의。
Objective To investigate theDynamic changes of serum fibrosis indices and alpha fetoprotein in patients with disease of the liver.Methods: 182 cases with disease of the liver by using chemiluminescence immunoassays to detect the content of hyaluronic(HA)、laminin(LN)、typeШprocol agen aminopeptide(PШNP)、col agen(C-Ⅳ)、hyaluronic acid (HA), total bile acid (TBA), and alpha-fetoprotein (AFP), The content of AFP relationship between liver function and compare the clinical value of combined detection of liver cirrhosis.Results The content of serum fibrosis and TBA, AFP in chronic hepatitis B, cirrhosis, severe hepatitis were significantly higher than those in normal control group (P<0.05~0.01); by with elevated in disease, levels; The content of HA with PTA, ALB, TBIL have a good correlation (r = -0372, -0.395, 0.344, P <0.05);The index of HA combination with PⅢNP diagnostic value were highest,The index of HA combination with P NP + CIV. diagnostic value were highest. CONCLUSION: It is definitely valuable to dynamical y inspect serum HA,PⅢP, LN and AFP level for the prognosis of liver cirrhosis.
