CAJ | 학술논문

糖皮质激素指的是人体的肾上腺分泌出的一类甾体激素，组织成分比较复杂，皮质醇占到70.8%左右，具有调节糖、脂肪等广泛的生理作用，另外还具有抗炎、抗毒、抗休克等作用。在临床上，糖皮质激素不仅诱导成熟的淋巴瘤细胞、肝癌细胞以及白血病细胞等凋亡，而且对未成熟的肿瘤细胞同样有效。根据相关研究表明，糖皮质激素作用于肿瘤细胞主要是通过与体内的糖皮质激素手受体相结合，激活体内与肿瘤细胞凋亡的一系列信号通路。对糖皮质激素诱导肿瘤细胞抗凋亡机制进行深入的研究对于治疗改疾病具有重要的作用和意义。
당피질격소지적시인체적신상선분비출적일류치체격소，조직성분비교복잡，피질순점도70.8%좌우，구유조절당、지방등엄범적생리작용，령외환구유항염、항독、항휴극등작용。재림상상，당피질격소불부유도성숙적림파류세포、간암세포이급백혈병세포등조망，이차대미성숙적종류세포동양유효。근거상관연구표명，당피질격소작용우종류세포주요시통과여체내적당피질격소수수체상결합，격활체내여종류세포조망적일계렬신호통로。대당피질격소유도종류세포항조망궤제진행심입적연구대우치료개질병구유중요적작용화의의。
Glucocorticoid (glucocorticoid, GCS) bundle with a class of steroid hormone secretion by the adrenal cortex, cortisol, have to adjust the sugar, fat, and protein biosynthesis and metabolism, but also inhibits the immune response, anti-inflammatory, anti-drug and anti-shock effect. In clinical practice, the glucocorticoid is not only induced lymphoma cel s mature, apoptosis of hepatoma cel s and leukemia cel s, etc., but equal y effective in the tumor cel s of immature. Research indicates that the glucocorticoid effect on tumor cel s mainly by the glucocorticoid hand vivo receptor combination, a series of signaling pathway activation in vivo tumor cel apoptosis. Glucocorticoid-induced tumor cel anti-apoptotic mechanism has an important role and significance of in-depth research for treatment change disease.