CAJ | 학술논문

目的检测乳腺癌组织中着丝粒蛋白CENP-H的表达，探讨其表达与乳腺癌的关系及意义。方法采用免疫组化SP 法检测CENP-H在61例乳腺癌石蜡组织切片中的表达，并采用SPSS19.0软件进行统计分析。结果61例乳腺癌组织中有24例CENP-H阳性表达（39.3%），而在正常乳腺组织中未见表达。统计分析结果发现CENP-H阳性表达与乳腺癌的临床分期及T分期密切相关。结论 CENP-H可能是评价乳腺癌发生、发展的重要生物学指标。
목적검측유선암조직중착사립단백CENP-H적표체，탐토기표체여유선암적관계급의의。방법채용면역조화SP 법검측CENP-H재61례유선암석사조직절편중적표체，병채용SPSS19.0연건진행통계분석。결과61례유선암조직중유24례CENP-H양성표체（39.3%），이재정상유선조직중미견표체。통계분석결과발현CENP-H양성표체여유선암적림상분기급T분기밀절상관。결론 CENP-H가능시평개유선암발생、발전적중요생물학지표。
Purpose To investigate the expression level and clinicopathologic significance of centromere protein H in breast cancer. Methods immunohistochemical analysis was used to examine the expression of CENP-H expressions in 61 cases of breast cancer tissues.Results24 tissues is positive expression of CENP-H in 61 tissues.Statistical analysis displayed that strong expression of CENP-H was significantly associated with clinical stage and T classification.Conclusion CENP-H may serve as a valuable molecular marker for prediction of breast cancer development and progression.