CAJ | 학술논문

目的探讨腹腔镜下直肠癌根治术和常规开腹手术对患者机体细胞免疫功能的影响。方法选择腹腔镜下直肠癌根治术患者20例和常规开腹手术患者20例，分别于术前第1d、术后第3、7 d空腹抽取患者外周静脉血5mL，对两组CD 3+、CD 4+、CD 8+、NK细胞水平进行检测和比较分析。结果腹腔镜组术前1d CD 3+、CD 4+、CD 8+和NK细胞水平与开腹组比较差异无显著性（P＞0.05）；腹腔镜组术后第3、7 d患者CD 3+、CD 4+、CD 8+和NK细胞均明显高于开腹手术组（P＜0.05）。结论腹腔镜直肠癌根治术对机体细胞免疫功能抑制程度明显小于开腹手术，术后患者机体恢复较早。
목적탐토복강경하직장암근치술화상규개복수술대환자궤체세포면역공능적영향。방법선택복강경하직장암근치술환자20례화상규개복수술환자20례，분별우술전제1d、술후제3、7 d공복추취환자외주정맥혈5mL，대량조CD 3+、CD 4+、CD 8+、NK세포수평진행검측화비교분석。결과복강경조술전1d CD 3+、CD 4+、CD 8+화NK세포수평여개복조비교차이무현저성（P＞0.05）；복강경조술후제3、7 d환자CD 3+、CD 4+、CD 8+화NK세포균명현고우개복수술조（P＜0.05）。결론복강경직장암근치술대궤체세포면역공능억제정도명현소우개복수술，술후환자궤체회복교조。
Objective To investigate the effects of laparoscopic radical operation and open on immune functions in patients with rectal carcinoma. Methods Forty patients with rectal carcinoma were divided into laparoscopic(20 cases) and open operation groups(20 cases). CD 3+cells, CD 4+cells CD 8+ cells and NK cells were counted and compared on the 1 st day before operation, and 3 th and 7 th day after operation. Results There were no differences on the 1 st day before operation between the two groups in CD 3+cells, CD 4+cells, CD 8+cells and NK cells;and the number of CD 3+cells, CD 4+cells, CD 8+cells and NK cells on the 3 th and 7 th day after operation in laparoscopic group was signiifcantly more than that in open operation group. Conclusion Compared with open operation group, laparoscopic radical operation is slighter in immune functions, and the revive was early.