CAJ | 학술논문

目的系统评价抗抑郁药治疗功能性消化不良的疗效及安全性。方法计算机检索1982年6月30日至2012年6月30日间中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）和万方数据库（ WANFANG）、Pubmed数据库及Cochrane 图书馆，查找抗抑郁药治疗功能性消化不良的随机对照试验（ RCT），同时手检纳入研究的参考文献。由2名评价者独立进行文献质量评价和资料提取后应用Stata 12.0软件进行分析评价。结果共纳入7项研究的656例患者。治疗使用的药物包括阿米替林、帕罗西汀、舍曲林及氟哌噻吨美利曲辛。结果显示：（1）抗抑郁药改善功能性消化不良总体症状缓解率（84.23％）明显高于常规治疗药物（55.60％）（RR＝1.51，95％CI：1.36～1.69，P＜0.05）。（2）抗抑郁药治疗组的不良反应发生率与常规治疗药物治疗组无显著性差异[ RR＝1.642，95％CI：0.747～3.606，P＞0.05]。结论抗抑郁药治疗功能性消化不良有效且安全，并优于其他西药。另因欠缺确切数据，故未对功能性消化不良各分型疗效、生存质量效果的专项统计。
목적계통평개항억욱약치료공능성소화불량적료효급안전성。방법계산궤검색1982년6월30일지2012년6월30일간중국기간전문수거고（CNKI）、중문과기기간전문수거고（VIP）화만방수거고（ WANFANG）、Pubmed수거고급Cochrane 도서관，사조항억욱약치료공능성소화불량적수궤대조시험（ RCT），동시수검납입연구적삼고문헌。유2명평개자독립진행문헌질량평개화자료제취후응용Stata 12.0연건진행분석평개。결과공납입7항연구적656례환자。치료사용적약물포괄아미체림、파라서정、사곡림급불고새둔미리곡신。결과현시：（1）항억욱약개선공능성소화불량총체증상완해솔（84.23％）명현고우상규치료약물（55.60％）（RR＝1.51，95％CI：1.36～1.69，P＜0.05）。（2）항억욱약치료조적불량반응발생솔여상규치료약물치료조무현저성차이[ RR＝1.642，95％CI：0.747～3.606，P＞0.05]。결론항억욱약치료공능성소화불량유효차안전，병우우기타서약。령인흠결학절수거，고미대공능성소화불량각분형료효、생존질량효과적전항통계。
Objective To systematically assess the efficacy and safety of antidepressants for functional dyspepsia( FD).Methods PubMed, The Cochrane Central Register of Controlled Trials Literature Database , National Knowledge Infrastructure ( CNKI ) , Wanfang Data Knowledge Service Platform and VIP Information were searched for randomized controlled trials ( RCT ) investigating the efficacy of antidepressants in the management of functional dyspepsia from June 30,1982 to June 30,2012,and at the same time the reference document were manually retrieved reviewers .All data were given Meta analysis by using StataSE 12.0 software.Results There were 7 RCT enclosed involving 656 patients.The therapeutic use of drugs,including amitriptyline,paroxetine,sertraline and flupentixol and melitracen tablets .( 1 ) Compared to conventional drugs ( 55.60%) , antidepressants ( 84.23%) were associated with a higher rate of global symptoms relief (RR=1.51,95% CI:1.36-1.69,P<0.05).(2)There was no significant difference in the incidence of serious adverse events between the antidepressants and conventional drugs groups(RR=1.642,95% CI:0.747-3.606,P>0.05).Conclusions Antidepressants may be effective and safe in relief of the symptoms of functional dyspepsia patients ,and superior to conventional drugs .Other,we have not assessed the efficacy of antidepressants to the various typing and the improving quality of life in functional dyspepsia for lack of precise data .