中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
3期
1097-1100
,共4页
湿疹%抗感染药%糖皮质激素类
濕疹%抗感染藥%糖皮質激素類
습진%항감염약%당피질격소류
Eczema%Anti-infecive agents%Glucocorticoids
目的比较曲安奈德益康唑乳膏与糠酸莫米松乳膏治疗持续性局限性湿疹的疗效与安全性及其对复发的影响。方法门诊持续性局限性湿疹患者220例，随机分两组，分别外用曲安奈德益康唑乳膏和糠酸莫米松乳膏，均治疗4周。达到临床治愈者随访24周，观察复发情况。结果急性及亚急性湿疹患者接受4周治疗后，曲安奈德益康唑组痊愈率（100％）高于糠酸莫米松组（57.9％），差异有统计学意义（ P＝0.005）。治疗慢性湿疹4周，曲安奈德益康唑组痊愈率与糠酸莫米松组差异无统计学意义（χ2＝0.224，P＝0.636）。曲安奈德益康唑组不良反应发生率（2.73％）与糠酸莫米松组（1.82％）差异无统计学意义（χ2＝0.000，P＝1.000），无严重不良反应。二者总复发率差异也无统计学意义（29.6％ vs．33.8％，χ2＝0.289， P＝0.591）。结论曲安奈德益康唑乳膏治疗急性亚急性湿疹疗效优于单方激素糠酸莫米松，在治疗慢性湿疹及预防复发方面二者相当。
目的比較麯安奈德益康唑乳膏與糠痠莫米鬆乳膏治療持續性跼限性濕疹的療效與安全性及其對複髮的影響。方法門診持續性跼限性濕疹患者220例，隨機分兩組，分彆外用麯安奈德益康唑乳膏和糠痠莫米鬆乳膏，均治療4週。達到臨床治愈者隨訪24週，觀察複髮情況。結果急性及亞急性濕疹患者接受4週治療後，麯安奈德益康唑組痊愈率（100％）高于糠痠莫米鬆組（57.9％），差異有統計學意義（ P＝0.005）。治療慢性濕疹4週，麯安奈德益康唑組痊愈率與糠痠莫米鬆組差異無統計學意義（χ2＝0.224，P＝0.636）。麯安奈德益康唑組不良反應髮生率（2.73％）與糠痠莫米鬆組（1.82％）差異無統計學意義（χ2＝0.000，P＝1.000），無嚴重不良反應。二者總複髮率差異也無統計學意義（29.6％ vs．33.8％，χ2＝0.289， P＝0.591）。結論麯安奈德益康唑乳膏治療急性亞急性濕疹療效優于單方激素糠痠莫米鬆，在治療慢性濕疹及預防複髮方麵二者相噹。
목적비교곡안내덕익강서유고여강산막미송유고치료지속성국한성습진적료효여안전성급기대복발적영향。방법문진지속성국한성습진환자220례，수궤분량조，분별외용곡안내덕익강서유고화강산막미송유고，균치료4주。체도림상치유자수방24주，관찰복발정황。결과급성급아급성습진환자접수4주치료후，곡안내덕익강서조전유솔（100％）고우강산막미송조（57.9％），차이유통계학의의（ P＝0.005）。치료만성습진4주，곡안내덕익강서조전유솔여강산막미송조차이무통계학의의（χ2＝0.224，P＝0.636）。곡안내덕익강서조불량반응발생솔（2.73％）여강산막미송조（1.82％）차이무통계학의의（χ2＝0.000，P＝1.000），무엄중불량반응。이자총복발솔차이야무통계학의의（29.6％ vs．33.8％，χ2＝0.289， P＝0.591）。결론곡안내덕익강서유고치료급성아급성습진료효우우단방격소강산막미송，재치료만성습진급예방복발방면이자상당。
Objective To compare the efficacy and safety between triamcinolone acetonide and econazole nitrate cream and mometasone furoate cream in the treatment of persistent localized eczema and their effect on recurrence.Methods 220 outpatients with localized eczema were randomized to treatment for 4 weeks with triamcinolone acetonide and econazole nitrate cream or mometasone furoate cream .Those whose symptom score reducing index (SSRI) more than 90% were followed up until 24 weeks after the discontinuation to observe the recurrence.Results After 4 weeks treatment the cure rate of triamcinolone acetonide and econazole nitrate group were significantly higher than that of mometasone furoate group in patients with acute and subacute eczema ( 100%vs.57.9%,chi-square test,P =0.005).There was no significant difference between the cure rates of these two groups in patients with chronic eczema after 4 weeks of treatment (χ2 =0.224 ,P=0.636 ) .No significant difference was found in the incidence rates of adverse effect between the two groups ( 2.73% vs.1.82%,χ2 =0.000 , P =1.000 ) .The adverse effects were mild .There was no significant difference between the recurrence rates of these two groups(29.6%vs.33.8%,χ2 =0.289,P=0.591).Conclusions Triamcinolone acetonide and econazole nitrate cream is superior to mometasone furoate cream in the treatment of acute and subacute eczema .The two creams are equal in the treatment of chronic eczema and preventing relapse of eczema .
