CAJ | 학술논문

目的探讨水痘合并皮肤及软组织感染的临床特征、细菌学特点以及预后等。方法对本院2007年1月至2010年1月收治的40例水痘合并皮肤及软组织感染病例进行回顾性分析。结果入组患者中，水痘皮肤及软组织感染发生率35.4%（40/113），为住院患者最主要的并发症。溶血性链球菌、金黄色葡萄球菌是水痘患者继发皮肤及软组织感染最常见病原菌。脓毒症休克是死亡的主要原因。本组水痘合并皮肤及软组织感染的患者无一进行水痘免疫接种。存活组和死亡组患者的白细胞（WBC）、血小板（PLT）PLT、丙氨酸氨基转移酶（ALT）、血清白蛋白（ALB）、凝血酶原活动度（PTA）、血肌酐（Cr）、C-反应蛋白（CRP）等指标差异具有统计学意义（P＜0.05）。结论水痘合并皮肤及软组织感染者病死率仍较高，积极进行脓毒性休克的预防及治疗尤为关键，接种水痘疫苗可能是从根本上降低并预防水痘并发症的重要举措。
목적탐토수두합병피부급연조직감염적림상특정、세균학특점이급예후등。방법대본원2007년1월지2010년1월수치적40례수두합병피부급연조직감염병례진행회고성분석。결과입조환자중，수두피부급연조직감염발생솔35.4%（40/113），위주원환자최주요적병발증。용혈성련구균、금황색포도구균시수두환자계발피부급연조직감염최상견병원균。농독증휴극시사망적주요원인。본조수두합병피부급연조직감염적환자무일진행수두면역접충。존활조화사망조환자적백세포（WBC）、혈소판（PLT）PLT、병안산안기전이매（ALT）、혈청백단백（ALB）、응혈매원활동도（PTA）、혈기항（Cr）、C-반응단백（CRP）등지표차이구유통계학의의（P＜0.05）。결론수두합병피부급연조직감염자병사솔잉교고，적겁진행농독성휴극적예방급치료우위관건，접충수두역묘가능시종근본상강저병예방수두병발증적중요거조。
Objective To investigate the clinical features, bacteriology and prognosis of skin and soft tissue infection in varicella cases. Methods Total of 40 cases of varicella combined with skin and soft tissue infection were analyzed from January 2007 to January 2010 in our hospital, retrospectively. Results The incidence of skin and soft tissue infection with varicella inpatient was 35.4%(40/113), accounting for the primary cause for admission. Group Aβ-hemolytic streptococcus (GABHS), Staphylococcus aureus (SA) were the two major pathogenies. The primary reason of death was septic shock. No patient with skin and soft tissue infection was vaccinated. The white blood cell (WBC), platele (PLT), alanine aminotransferase (ALT), albumin (ALB), prothrombin time activity (PTA), creatinine (Cr) and C-reactive protein (CRP) of survival group and death group were all with signiifcant differences (P<0.05). Conclusions The mortality of varicella combined with skin and soft tissue infection is high. It is essential to prevent and administrate septic shock. Varicella vaccination may be an important measure to radically reduce and prevent the complications of varicella.