CAJ | 학술논문

目的探讨慢性HBV携带者肝脏组织中白细胞介素12（IL-12）的表达及其意义。方法应用SP免疫组织化学法检测100例慢性HBV携带者肝脏组织中IL-12的表达情况，并与HBeAg、HBV DNA定量分析比较。结果 HBeAg阳性的携带者中IL-12阴性表达率高，HBeAg阴性者IL-12阳性表达率高（r =0.324，P =0.001）；HBV DNA水平低者IL-12阳性表达率高，HBV DNA水平高者IL-12阴性表达率高（r =-0.445，P =0.000）；免疫耐受者IL-12阴性表达率高，低或非复制期者IL-12阳性表达率高（r=0.569，P=0.000）。结论 IL-12参与HBV感染的慢性化进展与转归。
목적탐토만성HBV휴대자간장조직중백세포개소12（IL-12）적표체급기의의。방법응용SP면역조직화학법검측100례만성HBV휴대자간장조직중IL-12적표체정황，병여HBeAg、HBV DNA정량분석비교。결과 HBeAg양성적휴대자중IL-12음성표체솔고，HBeAg음성자IL-12양성표체솔고（r =0.324，P =0.001）；HBV DNA수평저자IL-12양성표체솔고，HBV DNA수평고자IL-12음성표체솔고（r =-0.445，P =0.000）；면역내수자IL-12음성표체솔고，저혹비복제기자IL-12양성표체솔고（r=0.569，P=0.000）。결론 IL-12삼여HBV감염적만성화진전여전귀。
Objective To investigate the expression levels of IL-12 in the liver of HBV carriers and explore its significance. Methods IL-12 expression was detected by immunohistochemistry SP method in liver tissues of HBV carriers (n=100). Results The levels of IL-12 in HBeAg positive HBV carriers were signiifcantly lower than those patients with HBeAg negative (r=0.324, P=0.001). The levels of IL-12 in HBV carriers with high HBV DNA were signiifcantly lower than those patients with low HBV DNA (r=-0.445, P=0.000). The levels of IL-12 in immune-tolerance carriers were lower than inactive carriers (r=0.569, P=0.000). Conclusion IL-12 may be involved in the chronic infection of HBV, the progress and prognosis of the disease.