CAJ | 학술논문

目的探讨肝脏病理炎症分级和纤维化分期与年龄、血清ALT、HBV DNA、HBeAg之间的关系。方法将已行肝组织病理检查的326例慢性乙型病毒性肝炎患者，根据年龄≥40岁或＜40岁、ALT≥80 IU/L或＜80 IU/L、HBV DNA≥107拷贝/ml或＜107拷贝/ml、HBeAg阳性或阴性各分为两组，分别探讨两组间肝脏病理炎症分级G0～1、G2、G3、G4和纤维化分期S0～1、S2、S3、S4的关系，通过χ2检验，从四个方面分析各组之间是否存在统计学差异。结果年龄大小和不同HBV-DNA水平两方面，两组间肝脏纤维化分期存在统计学差异（ P值分别为0.000和0.001），炎症分级无统计学差异；在不同的ALT水平和HBeAg阳性与否方面，两组间肝脏炎症分级存在统计学差异（ P值分别为0.000和0.044），纤维化分期无统计学差异。结论在慢性乙型病毒性肝炎患者中，年龄、HBV DNA 水平与肝脏病理的纤维化分期相关；ALT 水平、HBeAg阳性和肝脏病理的炎症分级相关。
목적탐토간장병리염증분급화섬유화분기여년령、혈청ALT、HBV DNA、HBeAg지간적관계。방법장이행간조직병리검사적326례만성을형병독성간염환자，근거년령≥40세혹＜40세、ALT≥80 IU/L혹＜80 IU/L、HBV DNA≥107고패/ml혹＜107고패/ml、HBeAg양성혹음성각분위량조，분별탐토량조간간장병리염증분급G0～1、G2、G3、G4화섬유화분기S0～1、S2、S3、S4적관계，통과χ2검험，종사개방면분석각조지간시부존재통계학차이。결과년령대소화불동HBV-DNA수평량방면，량조간간장섬유화분기존재통계학차이（ P치분별위0.000화0.001），염증분급무통계학차이；재불동적ALT수평화HBeAg양성여부방면，량조간간장염증분급존재통계학차이（ P치분별위0.000화0.044），섬유화분기무통계학차이。결론재만성을형병독성간염환자중，년령、HBV DNA 수평여간장병리적섬유화분기상관；ALT 수평、HBeAg양성화간장병리적염증분급상관。
Objective To discuss the relationship between inflammation classification and fibrosis stage of the liver pathology and age ,ALT,HBV DNA,HBeAg.Methods 326 patients with chronic hepatitis B who had have liver pathology were divided into two groups respectively according to the age more than forty or not ,ALT≥80 IU/L or not,HBV DNA≥107 copies/ml or not and HBeAg positive or negative .To discuss the relationship between the two groups of liver inflammation pathological grading G 0-1,G2,G3,G4 and fibrosis stage S0-1,S2,S3,S4.To analyse whether there were statistically significant differences from the four aspects through the chi -square test.Results In different age and different HBV-DNA level,liver fibrosis stage exist significant difference between the two groups ( P value were 0.000 and 0.001 ) and inflammation classification was not statistically significant .In different ALT level and HBeAg positive or not , liver inflammation classification statistical differences exist between the two groups ( P value were 0.000 and 0.001 ) and fibrosis stage was not statistically significant .Conclusions In chronic hepatitis B patients,age,HBV-DNA level and liver pathological fibrosis stage related ,while ALT level,HBeAg positive and inflammation of the liver pathology classification related .