CAJ | 학술논문

目的探讨颅咽管瘤患者手术后腺垂体生长激素储备功能状态。方法采用胰岛素耐受性试验（ insulin tolerance test ，ITT）对12例颅咽管瘤术后时间超过6个月以上的患者行动态腺垂体生长激素储备功能试验。结果本组所有患者ITT各时间点生长激素分泌的水平均低于1 ng/ml，提示本组受试者均存在完全性生长激素缺乏。受试者中4例患者的生长激素水平在ITT试验的各观察时间点波动在0.092～0.199 ng/ml，但仍低于1 ng/ml，其余8例患者生长激素水平在ITT激发后各观察时间点较前4例更低，其中4例患者各观察时间点生长激素水平甚至低于0.05 ng/ml。结论本组颅咽管瘤患者在手术治疗6个月以后均存在严重的腺垂体生长激素储备功能减退。
목적탐토로인관류환자수술후선수체생장격소저비공능상태。방법채용이도소내수성시험（ insulin tolerance test ，ITT）대12례로인관류술후시간초과6개월이상적환자행동태선수체생장격소저비공능시험。결과본조소유환자ITT각시간점생장격소분비적수평균저우1 ng/ml，제시본조수시자균존재완전성생장격소결핍。수시자중4례환자적생장격소수평재ITT시험적각관찰시간점파동재0.092～0.199 ng/ml，단잉저우1 ng/ml，기여8례환자생장격소수평재ITT격발후각관찰시간점교전4례경저，기중4례환자각관찰시간점생장격소수평심지저우0.05 ng/ml。결론본조로인관류환자재수술치료6개월이후균존재엄중적선수체생장격소저비공능감퇴。
Objective To investigate the reserved function of growth hormone ( GH ) in pituitary of the patients with craniopharyngioma after surgery .Methods By means of insulin tolerance test ( ITT) ,12 cases patients with craniopharyngioma , after surgery of more than six months , had been taken this dynamic endocrine test for evaluation the reserved function of GH in pituitary .Results All of the patients in this study ,the concentrations of GH at each measuring points were less than 1 ng/ml after ITT,it was indicate that there were absolutely deficiency of GH secretion after hypoglycemia induced by insulin infusion .During each observation point in ITT ,the GH secretion in 4 cases of the patients fluctuate between 0.092-0.199 ng/ml,but all of the test values at each measuring points still less than 1 ng/ml,the rest of 8 cases growth hormone level lower than the previous 4 cases,in which,4 cases of GH concentrations even less than 0.05 ng/ml at each measuring points .Conclusions In this study,patients with craniopharyngioma have absolutely GH deficiency in pituitary after surgery more than 6 months.