中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
4期
1458-1461
,共4页
乳腺肿瘤%卵泡抑素%黏蛋白类%酶联免疫吸附测定
乳腺腫瘤%卵泡抑素%黏蛋白類%酶聯免疫吸附測定
유선종류%란포억소%점단백류%매련면역흡부측정
Breast neoplasms%Follistatin%Mucins%Enzyme-linked immunosorbent assay
目的研究乳腺癌患者血清中卵泡抑素（ FS）和黏蛋白MUC1表达与肿瘤的发生发展与转移的关系及其临床意义。方法采集60例乳腺疾病入院患者的血清样本，其中乳腺癌40例，乳腺良性疾病20例，分别采用ELISA法和CanAgMUC1检测试剂盒检测其血清中FS和MUC1含量。结果在40例乳腺癌患者血清中FS和MUC1的血清含量分别为（3.75±1.32）ng/ml和（37.63±23.22）U/ml，FS和MUC1的阳性率分别为32.50％和47.50％，均明显高于对照组（ P＜0.01），乳腺癌患者FS和MUC1血清含量和阳性率与组织学分级、肿瘤大小、腋窝淋巴结转移有关（ P＜0.01或P＜0.05）。结论 FS、MUC1与肿瘤发生、发展、生物学特征以及转移密切相关，联合检测这些指标有利于乳腺癌的早期诊断以及预后判断。
目的研究乳腺癌患者血清中卵泡抑素（ FS）和黏蛋白MUC1錶達與腫瘤的髮生髮展與轉移的關繫及其臨床意義。方法採集60例乳腺疾病入院患者的血清樣本，其中乳腺癌40例，乳腺良性疾病20例，分彆採用ELISA法和CanAgMUC1檢測試劑盒檢測其血清中FS和MUC1含量。結果在40例乳腺癌患者血清中FS和MUC1的血清含量分彆為（3.75±1.32）ng/ml和（37.63±23.22）U/ml，FS和MUC1的暘性率分彆為32.50％和47.50％，均明顯高于對照組（ P＜0.01），乳腺癌患者FS和MUC1血清含量和暘性率與組織學分級、腫瘤大小、腋窩淋巴結轉移有關（ P＜0.01或P＜0.05）。結論 FS、MUC1與腫瘤髮生、髮展、生物學特徵以及轉移密切相關，聯閤檢測這些指標有利于乳腺癌的早期診斷以及預後判斷。
목적연구유선암환자혈청중란포억소（ FS）화점단백MUC1표체여종류적발생발전여전이적관계급기림상의의。방법채집60례유선질병입원환자적혈청양본，기중유선암40례，유선량성질병20례，분별채용ELISA법화CanAgMUC1검측시제합검측기혈청중FS화MUC1함량。결과재40례유선암환자혈청중FS화MUC1적혈청함량분별위（3.75±1.32）ng/ml화（37.63±23.22）U/ml，FS화MUC1적양성솔분별위32.50％화47.50％，균명현고우대조조（ P＜0.01），유선암환자FS화MUC1혈청함량화양성솔여조직학분급、종류대소、액와림파결전이유관（ P＜0.01혹P＜0.05）。결론 FS、MUC1여종류발생、발전、생물학특정이급전이밀절상관，연합검측저사지표유리우유선암적조기진단이급예후판단。
Objective To investigate the connection between the expression of FS and MUC 1 proteins in the breast cancer patients serum and tumor growth and metastasis ,and to explore the clinical significance .Methods By using ELISA method and CanAgMUC 1 to examine the expression levels of FS and MUC 1 proteins in 40 serum samples of breast cancer patients and 20 serum samples of breast benign disease .Results In 40 cases of breast cancer patients serum,the content of FS and MUC1 were(3.75 ±1.32)ng/ml and(37.63 ±23.22)U/ml,the positive rate were 32.50%and 47.50%,which were significantly higher than those in the control group ( P<0.01 ) . The content and positive rate of FS and MUC 1 proteins in the breast cancer patients serum were positively correlated to histological grade,tumor size,axillary lymph node metastatic carcinoma (P<0.01 or P<0.05).Conclusions FS and MUC1 proteins were closely related to tumoral occurrence , development , biological characteristics and transfer , and testing of the two proteins together will be helpful to the early diagnosis of breast cancer and prognostic judgement .
