CAJ | 학술논문

目的探讨p130Cas 在卵巢上皮性癌中的表达及意义。方法应用免疫组化方法检测p130 Cas在80例卵巢上皮性癌和30例正常卵巢组织中的表达，并分析其表达与肿瘤临床病理因素及预后的相关性。结果 p130Cas 在卵巢上皮性癌中的阳性表达率高于其在正常卵巢组织中的表达（73.75％ vs．10.00％，P＜0.001）；在卵巢上皮性癌中，FIGOⅢ期患者p130Cas 阳性表达率高于FIGO分期Ⅰ＋Ⅱ患者（84.6％vs．56.8％，P＝0.005）；p130Cas高表达的患者有更差的卵巢癌特异性5年累计生存率（P＝0.002），经多因素分析有统计学意义（ P＝0.036）。结论 p130 Cas高表达可能促进卵巢上皮性癌的发生，并与其更晚的分期和不良预后相关。
목적탐토p130Cas 재란소상피성암중적표체급의의。방법응용면역조화방법검측p130 Cas재80례란소상피성암화30례정상란소조직중적표체，병분석기표체여종류림상병리인소급예후적상관성。결과 p130Cas 재란소상피성암중적양성표체솔고우기재정상란소조직중적표체（73.75％ vs．10.00％，P＜0.001）；재란소상피성암중，FIGOⅢ기환자p130Cas 양성표체솔고우FIGO분기Ⅰ＋Ⅱ환자（84.6％vs．56.8％，P＝0.005）；p130Cas고표체적환자유경차적란소암특이성5년루계생존솔（P＝0.002），경다인소분석유통계학의의（ P＝0.036）。결론 p130 Cas고표체가능촉진란소상피성암적발생，병여기경만적분기화불량예후상관。
Objective To investigate the expression of p 130Cas protein in epithelial ovarian carcinoma and normal ovarian tissue ,and assess their correlations with clinicopathological parameters and prognosis .Methods The expression level of p130Cas in epithelial ovarian carcinoma and normal ovarian tissue samples was measured by immunohistochemistry.Results The expression of p130Cas in epithelial ovarian carcinoma was higher than normal ovarian tissue(73.75%vs.10.00%,P<0.001).In epithelial ovarian cancer ,p130Cas expression was significantly higher in FIGO Ⅲ stage than in FIGO Ⅰ+Ⅱ stage(84.6% vs.56.8%,P =0.005).In addition,patients with p130 Cas high expression had poor survival ( P =0.002 in univariate and P =0.036 in multivariate analysis ) . Conclusions p130 Cas may positively regulate carcinogenesis , and correlate with advanced FIGO stage and poor prognosis in epithelial ovarian carcinoma .