中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2013年
4期
402-404
,共3页
王艳炜%高树军%赵长增%齐书英
王豔煒%高樹軍%趙長增%齊書英
왕염위%고수군%조장증%제서영
肌钙蛋白I%尿酸%冠心病%冠脉病变
肌鈣蛋白I%尿痠%冠心病%冠脈病變
기개단백I%뇨산%관심병%관맥병변
Troponin I%Uric acid%Coronary heart disease%Coronary artery lesions
目的探讨冠状动脉不同病变程度的血浆肌钙蛋白I（TnI）、尿酸（UA）的水平变化。方法选择经冠状动脉造影确诊的冠心病患者80例纳入冠心病组，同期纳入非冠心病患者26例作为对照组，其中冠心病组又按照病变支数分为单支病变组（n=29），双支病变组（n=29），多支病变组（n=22）。采用累计积分法计算所有患者冠状动脉狭窄程度，分别测定各组平均血TnI、UA水平，并对TnI、UA与冠状动脉狭窄程度的相关性进行统计学分析。结果对照组患者血TnI、UA值分别为（0.014±0.01）μg/L及（295.682±45.43）μmol/L；冠脉单支病变组、双支病变组及多支病变组的TnI值分别为（5.453±12.29）μg/L、（16.022±28.56）μg/L和（20.552±30.25）μg/L，血UA值分别为（357.821±74.91）μmol/L、（389.907±82.19）μmol/L和（401.122±83.81）μmol/L。冠心病组患者TnI和UA水平均值明显高于对照组，差异有统计学意义（P均＜0.05）。同时，冠心病多支病变组TnI水平与单支病变组比较更高，差异具有统计学意义（P＜0.05）；冠心病其余各两组间TnI、UA水平比较无统计学差异（P＞0.05）。TnI、UA水平均与冠状动脉狭窄程度呈显著性正相关（r值分别为0.673及0.440，P＜0.01）。结论冠心病患者的TnI和UA水平显著增高，而且冠脉病变程度越重，升高越明显。
目的探討冠狀動脈不同病變程度的血漿肌鈣蛋白I（TnI）、尿痠（UA）的水平變化。方法選擇經冠狀動脈造影確診的冠心病患者80例納入冠心病組，同期納入非冠心病患者26例作為對照組，其中冠心病組又按照病變支數分為單支病變組（n=29），雙支病變組（n=29），多支病變組（n=22）。採用纍計積分法計算所有患者冠狀動脈狹窄程度，分彆測定各組平均血TnI、UA水平，併對TnI、UA與冠狀動脈狹窄程度的相關性進行統計學分析。結果對照組患者血TnI、UA值分彆為（0.014±0.01）μg/L及（295.682±45.43）μmol/L；冠脈單支病變組、雙支病變組及多支病變組的TnI值分彆為（5.453±12.29）μg/L、（16.022±28.56）μg/L和（20.552±30.25）μg/L，血UA值分彆為（357.821±74.91）μmol/L、（389.907±82.19）μmol/L和（401.122±83.81）μmol/L。冠心病組患者TnI和UA水平均值明顯高于對照組，差異有統計學意義（P均＜0.05）。同時，冠心病多支病變組TnI水平與單支病變組比較更高，差異具有統計學意義（P＜0.05）；冠心病其餘各兩組間TnI、UA水平比較無統計學差異（P＞0.05）。TnI、UA水平均與冠狀動脈狹窄程度呈顯著性正相關（r值分彆為0.673及0.440，P＜0.01）。結論冠心病患者的TnI和UA水平顯著增高，而且冠脈病變程度越重，升高越明顯。
목적탐토관상동맥불동병변정도적혈장기개단백I（TnI）、뇨산（UA）적수평변화。방법선택경관상동맥조영학진적관심병환자80례납입관심병조，동기납입비관심병환자26례작위대조조，기중관심병조우안조병변지수분위단지병변조（n=29），쌍지병변조（n=29），다지병변조（n=22）。채용루계적분법계산소유환자관상동맥협착정도，분별측정각조평균혈TnI、UA수평，병대TnI、UA여관상동맥협착정도적상관성진행통계학분석。결과대조조환자혈TnI、UA치분별위（0.014±0.01）μg/L급（295.682±45.43）μmol/L；관맥단지병변조、쌍지병변조급다지병변조적TnI치분별위（5.453±12.29）μg/L、（16.022±28.56）μg/L화（20.552±30.25）μg/L，혈UA치분별위（357.821±74.91）μmol/L、（389.907±82.19）μmol/L화（401.122±83.81）μmol/L。관심병조환자TnI화UA수평균치명현고우대조조，차이유통계학의의（P균＜0.05）。동시，관심병다지병변조TnI수평여단지병변조비교경고，차이구유통계학의의（P＜0.05）；관심병기여각량조간TnI、UA수평비교무통계학차이（P＞0.05）。TnI、UA수평균여관상동맥협착정도정현저성정상관（r치분별위0.673급0.440，P＜0.01）。결론관심병환자적TnI화UA수평현저증고，이차관맥병변정도월중，승고월명현。
Objective To investigate the changes of troponin I (TnI) and uric acid (UA) in the patients with coronary artery lesions in varying degrees. Methods The patients with coronary heart disease (CHD) diagnosed by coronary angiography (CAG) were chosen as CHD group (n=80) and the cases without CHD as non-CHD group (n=26). The CHD group was divided again into single-vessel group (n=29), double-vessel group (n=29) and multi-vessel group (n=22) according to the number of diseased coronary vessels. The stenosis degree of coronary arteries was calculated by using accumulative integration method. The levels of TnI and UA were detected and the correlation between the levels of TnI and UA and stenosis degree of coronary arteries was analyzed statistically. Results The levels of TnI and UA were, respectively, (0.014±0.01) μg/L and (295.682±45.43) μmol/L in control group. The level of TnI was, respectively, (5.453±12.29)μg/L, (16.022±28.56)μg/L and (20.552± 30.25)μg/L, and UA, respectively, (357.821±74.91)μmol/L, (389.907±82.19)μmol/L and (401.122±83.81)μmol/L in single-vessel group, double-vessel group and multi-vessel group. The levels of TnI and UA were significantly higher in CHD group than those in control group (P<0.05), and meanwhile, those were higher in multi-vessel group than those in single-vessel group (P<0.05). The difference in levels of TnI and UA had no statistical significance between double-vessel group and multi-vessel group (P>0.05). The levels of TnI and UA were positively correlated to the stenosis degree of coronary arteries (r=0.673, r=0.440, P<0.01). Conclusion The levels of TnI and UA increase significantly in CHD patients, and the severe of coronary artery lesions is correlated to the levels of TnI and UA.
