CAJ | 학술논문

目的比较不同类高血压药物在未治疗的单纯舒张期高血压患者中的短期疗效。方法纳入初发单纯舒张期高血压患者104例，年龄40岁～75岁，随机分为四个药物治疗组：①双氢克尿噻组（n=37）：予双氢克尿噻（12.5～25）mg/d；②阿替洛尔组（n=19）：予阿替洛尔（12.5～25）mg/d；③硝苯地平缓释片组（n=27）：予硝苯地平缓释片（20～40）mg/d；④卡托普利组（n=21）：予卡托普利（25～50）mg/d。比较干预4周后的治疗效果差异。结果治疗4周后所有患者舒张压均有明显下降（P＜0.001），校正年龄、性别、体质指数、腰围、腰臀比、治疗前相应的血压值、血脂、血糖、吸烟、饮酒等传统危险因素后，四组间无统计学差异，但双氢克尿噻和硝苯地平较阿替洛尔和卡托普利降低收缩压的作用更明显（P＜0.05）。结论阿替洛尔和卡托普利对收缩压影响较小，更适合单纯舒张期高血压患者的降压治疗。
목적비교불동류고혈압약물재미치료적단순서장기고혈압환자중적단기료효。방법납입초발단순서장기고혈압환자104례，년령40세～75세，수궤분위사개약물치료조：①쌍경극뇨새조（n=37）：여쌍경극뇨새（12.5～25）mg/d；②아체락이조（n=19）：여아체락이（12.5～25）mg/d；③초분지평완석편조（n=27）：여초분지평완석편（20～40）mg/d；④잡탁보리조（n=21）：여잡탁보리（25～50）mg/d。비교간예4주후적치료효과차이。결과치료4주후소유환자서장압균유명현하강（P＜0.001），교정년령、성별、체질지수、요위、요둔비、치료전상응적혈압치、혈지、혈당、흡연、음주등전통위험인소후，사조간무통계학차이，단쌍경극뇨새화초분지평교아체락이화잡탁보리강저수축압적작용경명현（P＜0.05）。결론아체락이화잡탁보리대수축압영향교소，경괄합단순서장기고혈압환자적강압치료。
Objective To compare the short-term curative effect of different anti-hypertensive drugs in the untreated patients with isolated diastolic hypertension. Methods The patients (n=104, aged from 40 to 75) with isolated diastolic hypertension for the first time were chosen, and then divided into four groups:hydrochlorothiazide group (n=37,12.5 mg/d-25 mg/d), atenolol group (n=19, 12.5 mg/d-25 mg/d), nifedipine group (n=27, 20 mg/d-40 mg/d) and captopril group (n=21, 25 mg/d-50 mg/d). The curative effect was compared after four weeks. Results The diastolic blood pressure was significantly decreased in all patients after treatment for four weeks. After adjusting age, sex, body mass index, waistline and waist-hip ratio, and relative blood pressure, blood fat, blood sugar, smoking and drinking before treatment, there was no statistical difference among four groups. But hydrochlorothiazide and nifedipine had more significant effect of reducing diastolic blood pressure compared with atenolol (P=0.040) and captopril (P=0.016). Conclusion Atenolol and captopril have less effects on diastolic blood pressure, so they are more suitable for the patients with isolated diastolic hypertension.