CAJ | 학술논문

聚酮化合物具有抗感染、抗真菌、抗肿瘤、免疫抑制等生物活性，在临床上应用非常广泛。我们简要介绍了3种聚酮合酶的基因簇特点，即以模块形式存在的Ⅰ型聚酮合酶、包含重复使用结构域的Ⅱ型聚酮合酶和以查尔酮酶为代表的Ⅲ型聚酮合酶，以及大环内酯类、四环素类、蒽环类、聚醚类聚酮化合物异源表达研究现状，综述了异源表达宿主在不同聚酮化合物的表达方面存在的优势及其挑战。
취동화합물구유항감염、항진균、항종류、면역억제등생물활성，재림상상응용비상엄범。아문간요개소료3충취동합매적기인족특점，즉이모괴형식존재적Ⅰ형취동합매、포함중복사용결구역적Ⅱ형취동합매화이사이동매위대표적Ⅲ형취동합매，이급대배내지류、사배소류、은배류、취미류취동화합물이원표체연구현상，종술료이원표체숙주재불동취동화합물적표체방면존재적우세급기도전。
Polyketides are a large family of natural products with important bioactivity in clinical application in-cluding anti-inflammatory, antifungal, antitumor, immunosuppressive agents. In this paper, three types of polyketide synthases(PKS), the modular(typeⅠ) PKS, the typeⅡ PKS containing the repeat domain and the type Ⅲ PKS (chalcone synthase-like protein), were introduced. In addition, the advantages and challenges of heterologous ex-pression of polyketide compounds including macrolides, tetracyclines, anthracyclines, polyethers were also reviewed.