CAJ | 학술논문

恶性肿瘤细胞迁移是一个非常重要的临床问题，也是导致癌症患者死亡的主要原因之一。N-myc下游调节基因1（NDRG-1）是近年发现的与细胞分化相关的基因，在阻止肿瘤细胞入侵和迁移，尤其是抑制肿瘤组织生长的过程中扮演着非常重要的角色。该基因可以被多种分化调节剂诱导表达。我们就影响其表达的几个典型因素做简要综述。
악성종류세포천이시일개비상중요적림상문제，야시도치암증환자사망적주요원인지일。N-myc하유조절기인1（NDRG-1）시근년발현적여세포분화상관적기인，재조지종류세포입침화천이，우기시억제종류조직생장적과정중분연착비상중요적각색。해기인가이피다충분화조절제유도표체。아문취영향기표체적궤개전형인소주간요종술。
Tumor metastasis is a very important clinical issue, which results from the majority of cancer-related deaths. N-myc downstream-regulated gene-1(NDRG-1), a new tumor metastasis suppressor gene, plays an impor-tant role in preventing the invasion and migration of tumor cell, especially of inhibiting the growth of tumor tis-sue. NDRG-1 expression can be regulated by many differentiation regulators. In this review we reported the cur-rent research status of its influencing factors.