生物技术通讯
生物技術通訊
생물기술통신
LETTERS IN BIOTECHNOLOGY
2013年
4期
558-561
,共4页
arrest defective-1%N- 乙酰基转移酶%功能%肿瘤
arrest defective-1%N- 乙酰基轉移酶%功能%腫瘤
arrest defective-1%N- 을선기전이매%공능%종류
arrest defective-1%N-acetyltransferase%function%tumour
N-乙酰基转移酶ARD1（arrest defective-1）在蛋白翻译后将乙酰CoA中的乙酰基转移至N端的α氨基或赖氨酸残基的ε氨基。人和小鼠具有ARD1不同的变体，它们具有高度保守的N-乙酰基转移酶区域。ARD1分布于多种组织，定位于胞浆或细胞核内。现已发现ARD1基因与某些肿瘤的发生关系密切，是治疗肿瘤的一个潜在靶标。我们简要探讨了N-乙酰基转移酶ARD1基因的功能及其与肿瘤的关系。
N-乙酰基轉移酶ARD1（arrest defective-1）在蛋白翻譯後將乙酰CoA中的乙酰基轉移至N耑的α氨基或賴氨痠殘基的ε氨基。人和小鼠具有ARD1不同的變體，它們具有高度保守的N-乙酰基轉移酶區域。ARD1分佈于多種組織，定位于胞漿或細胞覈內。現已髮現ARD1基因與某些腫瘤的髮生關繫密切，是治療腫瘤的一箇潛在靶標。我們簡要探討瞭N-乙酰基轉移酶ARD1基因的功能及其與腫瘤的關繫。
N-을선기전이매ARD1（arrest defective-1）재단백번역후장을선CoA중적을선기전이지N단적α안기혹뢰안산잔기적ε안기。인화소서구유ARD1불동적변체，타문구유고도보수적N-을선기전이매구역。ARD1분포우다충조직，정위우포장혹세포핵내。현이발현ARD1기인여모사종류적발생관계밀절，시치료종류적일개잠재파표。아문간요탐토료N-을선기전이매ARD1기인적공능급기여종류적관계。
N-acetyltransferase arrest defective-1(ARS1) is responsible for the post-transcriptional removal of ace-tyl group in the acetyl coenzyme A to α-amide or ε-amide of the lysine in the N-terminal. There are different variants in human and mouse, which shared a well-conserved N-acetyltransferase domain. ARD1 is distributed among multifarious tissues, located in cytoplasm or nucleolus. It has been found that ARD1 has an intimate rela-tionship with the occurrence of some tumours and can act as a potential target for curing tumour. In this paper we discussed the function of ARD1 and its relationship with tumour.
