CAJ | 학술논문

目的：探讨肾康注射液联合血液透析治疗慢性肾功能衰竭（CRF）患者的临床疗效。方法：将41例慢性肾衰终末期维持血透患者随机分成肾康注射液治疗组（简称治疗组）19例和单纯血透治疗对照组（简称对照组）22例，两组均进行标准的透析方法，在对症处理相同的条件下维持血透治疗。对照组每周3次血液透析治疗，治疗组在进行对症治疗的基础上，每周透析2次，每次透析完后给予肾康注射液。分别观察两组患者血肌酐（Scr）和血尿素氮（BUN）水平、透析充分性、营养状况、中医证候等方面的变化。结果：治疗组与对照组在肾功能、透析充分性、营养指标及电解质方面均无显著差异（P跃0.05）；治疗组中医证候疗效总有效率84.21%，对照组45.45%，治疗组优于对照组（P<0.05）；两组肌肤甲错、肢体麻木、大便干结症状改善不明显，差异无统计学意义（P跃0.05）；倦怠乏力、气短懒言、食少纳呆、头晕、头痛、腰痛、自汗症状改善明显，差异有统计学意义（P<0.05），治疗组优于对照组。两组在治疗前后均进行了三大常规、心电图、肝功能、肾功能、电解质检查，无异常表现。治疗组患者在使用肾康注射液期间，未发现有明显不良反应，安全性较好。结论：肾康注射液联合血液透析治疗慢性肾功能衰竭，能够改善患者的临床症状，提高患者的生活质量。在达到充分透析的情况下，肾康注射液有可能减少每周的透析次数。
목적：탐토신강주사액연합혈액투석치료만성신공능쇠갈（CRF）환자적림상료효。방법：장41례만성신쇠종말기유지혈투환자수궤분성신강주사액치료조（간칭치료조）19례화단순혈투치료대조조（간칭대조조）22례，량조균진행표준적투석방법，재대증처리상동적조건하유지혈투치료。대조조매주3차혈액투석치료，치료조재진행대증치료적기출상，매주투석2차，매차투석완후급여신강주사액。분별관찰량조환자혈기항（Scr）화혈뇨소담（BUN）수평、투석충분성、영양상황、중의증후등방면적변화。결과：치료조여대조조재신공능、투석충분성、영양지표급전해질방면균무현저차이（P약0.05）；치료조중의증후료효총유효솔84.21%，대조조45.45%，치료조우우대조조（P<0.05）；량조기부갑착、지체마목、대편간결증상개선불명현，차이무통계학의의（P약0.05）；권태핍력、기단라언、식소납태、두훈、두통、요통、자한증상개선명현，차이유통계학의의（P<0.05），치료조우우대조조。량조재치료전후균진행료삼대상규、심전도、간공능、신공능、전해질검사，무이상표현。치료조환자재사용신강주사액기간，미발현유명현불량반응，안전성교호。결론：신강주사액연합혈액투석치료만성신공능쇠갈，능구개선환자적림상증상，제고환자적생활질량。재체도충분투석적정황하，신강주사액유가능감소매주적투석차수。
This study was aimed to explore the clinical efficacy of Shen-Kang Injection (SKI) combined with hemodialysis in the treatment of chronic renal failure (CRF) patients. A total of 41 end-stage CRF patients under the hemodialysis treatment were randomly divided into the SKI treatment group of 19 cases and a control group of 22 cases. Both groups were treated with standard dialysis and the hemodialysis was maintained in the same symp-tomatic treatment conditions. Patients in the control group underwent three hemodialysis treatments in one week, while those in the treatment group were given hemodialysis twice a week based on the symptomatic treatment. And SKI was given after each time of hemodialysis in the treatment group. Indexes and changes in serum creati-nine (Scr), blood urea nitrogen (BUN) level, dialysis adequacy, nutrition status, traditional Chinese medicine ( TCM ) syndrome and other aspects of both groups were observed . The results showed that in the treatment group and control group, there were no significant differences in the renal function, dialysis adequacy, nutrition indica-tors and electrolyte ( P > 0 . 05 ) . In the treatment group , the total efficiency of TCM syndrome was 84 . 21%. And the total efficiency of TCM syndrome in the control group was 45.45%. The treatment group was better than the control group (P < 0.05). Symptoms such as scaly dry skin, numbness of the four limbs and dry stool were not obviously improved . And there was no statistical significance ( P > 0 . 05 ) . Symptoms such as fatigue , shortness of breath, poor appetite, dizziness, headache, lower back pain and spontaneous sweating were improved significantly. And there was statistical significance ( P < 0 . 05 ) . The treatment group was better than the control group . There were no abnormalities in the routine tests of blood, urine and stool, electrocardiogram, liver function, renal func-tion and electrolyte. In the treatment group, there was no significant adverse reactions during patients received SKI. The SKI has good safety. It was concluded that SKI combined with hemodialysis in the treatment of CRF is able to improve the clinical symptoms of patients and improve the patients' quality of life. When patient received adequate dialysis, SKI may reduce the dialysis frequency per week.